黄芩甙
黄芩甙(Baicalin)
CAS: 21967-41-9;100647-26-5
化学式: C21H18O11
| 中文名 | 黄芩甙 |
| 英文名 | Baicalin |
| 别名 | 黄芩苷 黄芩素 贝加灵 黄芩甙 黄芩苷(贝加灵,黄芩素-7-O-Β-D-葡萄糖醛酸苷) |
| 英文别名 | Radix Bassora Baicalin BAICALIN HYDRATE Baicalein 7-O-glucuronide BAICALIN 7-BETA-D-GLUCOPYRANOSIDURONATE HYDRATE BAICALEIN 7-BETA-D-GLUCOPYRANOSIDURONATE HYDRATE 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl hexopyranosiduronic acid 5,6-Dihydroxy-4-oxygen-2-phenyl-4H-1-benzopyran-7-beta-D-glucopyranose acid 5,6-Dihydroxy-4-oxygen-2-phenyl-4H-1-benzopyran-7-beta-D-glucopyranose acid 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid |
| CAS | 21967-41-9 100647-26-5 |
| EINECS | 606-866-1 |
| 化学式 | C21H18O11 |
| 分子量 | 446.36 |
| InChI | InChI=1/C21H18O11/c22-9-6-10(8-4-2-1-3-5-8)30-11-7-12(14(23)15(24)13(9)11)31-21-18(27)16(25)17(26)19(32-21)20(28)29/h1-7,16-19,21,23-27H,(H,28,29) |
| InChIKey | IKIIZLYTISPENI-ZFORQUDYSA-N |
| 密度 | 1.737±0.06 g/cm3(Predicted) |
| 熔点 | 202-205 °C (dec.) (lit.) |
| 沸点 | 836.6±65.0 °C(Predicted) |
| 比旋光度 | -85 º (c=1, DMSO) |
| 闪点 | 297.2°C |
| 蒸汽压 | 1.07E-29mmHg at 25°C |
| 溶解度 | DMSO (微溶) 、甲醇 (微溶) |
| 折射率 | 1.739 |
| 酸度系数 | 2.72±0.70(Predicted) |
| 存储条件 | 2-8°C |
| 稳定性 | 吸湿性 |
| 外观 | 固体 |
| 颜色 | Pale Yellow to Yellow |
| 物化性质 | 易溶于N，N-二甲基甲酰胺，吡啶中，可溶于碳酸氢钠、碳酸钠、氢氧化钠等碱性溶液中，但在碱液中不稳定，渐变暗棕色，微溶于热冰醋酸，难溶于甲酸、乙酸、丙酮，几乎不溶于水，乙醚、 苯、氯仿等。 来源于本品为双子叶植物唇形科 Labiatae 黄芩 Scutellaria baicalensis Georgi 的干燥根提取而得。 |
| MDL号 | MFCD00134418 |
| 危险品标志 | Xi - 刺激性物品 |
| 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
| 安全术语 | S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 |
| WGK Germany | 3 |
| RTECS | LZ5776910 |
| 海关编号 | 29329990 |
| 下游产品 | 黄芩苷甲酯 |
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[IF=3.738] Selma Houchi et al."Investigation of common chemical components and inhibitory effect on GES-type β-lactamase (GES22) in methanolic extracts of Algerian seaweeds."Microb Pathogenesis. 2019 Jan;126:56 83. [IF=3.205] Xianhua Zhang et al."Pharmacokinetic study of representative anti-oxidative compounds from Denshen-Chuanxiong-Honghua following oral administration in rats."J Chromatogr B. 2017 May;1052:82 84. [IF=9.381] Ya Zhao et al."Polysaccharide from vinegar baked radix bupleuri as efficient solubilizer for water-insoluble drugs of Chinese medicine."Carbohyd Polym. 2020 Feb;229:115473 85. [IF=6.17] Liang Shi et al."Baicalin promotes liver regeneration after acetaminophen-induced liver injury by inducing NLRP3 inflammasome activation."Free Radical Bio Med. 2020 Nov;160:163 86. [IF=5.875] Yumei Wu et al."Brain targeting of Baicalin and Salvianolic acid B combination by OX26 functionalized nanostructured lipid carriers."Int J Pharmaceut. 2019 Nov;571:118754 87. [IF=5.833] Zhou Zhidu et al."Ultra-sensitive amperometric determination of quercetin by using a glassy carbon electrode modified with a nanocomposite prepared from aminated graphene quantum dots, thiolated β-cyclodextrin and gold nanoparticles."Microchim Acta. 2020 88. [IF=5.81] Zhenyu Fan et al."Baicalin Prevents Myocardial Ischemia/Reperfusion Injury Through Inhibiting ACSL4 Mediated Ferroptosis."Front Pharmacol. 2021; 12: 628988 89. [IF=5.81] Cui Lihua et al."Chaihu Guizhi Ganjiang Decoction Ameliorates Pancreatic Fibrosis via JNK/mTOR Signaling Pathway."Front Pharmacol. 2021 Jun;0:1369 90. [IF=5.34] Shihao Yan et al."Network pharmacology-based identification of significant pathway for protection of Yinhuang granule in a mice model of metabolic-associated fatty liver disease."Phytomedicine. 2021 Oct;91:153666 91. [IF=5.279] Yanan Gao et al."Galactosylation of Monosaccharide Derivatives of Glycyrrhetinic Acid by UDP-Glycosyltransferase GmSGT2 from Glycine max."J Agr Food Chem. 2020;68(32):8580–8588 92. [IF=5.246] Sui Xinbing et al."Baicalin Induces Apoptosis and Suppresses the Cell Cycle Progression of Lung Cancer Cells Through Downregulating Akt/mTOR Signaling Pathway."Front Mol Biosci. 2021 Jan;0:323 93. [IF=5.11] Xiaonan Liu et al."De Novo Biosynthesis of Multiple Pinocembrin Derivatives in Saccharomyces cerevisiae."Acs Synth Biol. 2020;9(11):3042–3051 94. [IF=4.759] Yueping Jiang et al."Application of multifold characteristic ion filtering combined with statistical analysis for comprehensive profiling of chemical constituents in anti-renal interstitial fibrosis I decoction by ultra-high performance liquid chromatogra 95. [IF=4.759] Yi Zhang et al."Screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis."J Chromatogr A. 2020 Feb;1613:460625 96. [IF=4.545] Xiangyan Wu et al."Qingda granules attenuate hypertensive cardiac remodeling and inflammation in spontaneously hypertensive rats."Biomed Pharmacother. 2020 Sep;129:110367 97. [IF=4.225] Wu Dandan et al."Baicalin Protects Against Hypertension-Associated Intestinal Barrier Impairment in Part Through Enhanced Microbial Production of Short-Chain Fatty Acids."Front Pharmacol. 2019 Oct;0:1271 98. [IF=4.162] Leyi Ma et al."Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway."Drug Des Dev Ther. 2021; 15: 3207–3221 99. [IF=3.935] Chenglong Sun et al."A spatially-resolved approach to visualize the distribution and biosynthesis of flavones in Scutellaria baicalensis Georgi."J Pharmaceut Biomed. 2020 Feb;179:113014 100. [IF=3.935] Meng Chen et al."Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate."J Pharmaceut Biomed. 2021 Feb;195:113820 101. [IF=3.935] Zhengchao Ji et al."Global identification and quantitative analysis of representative components of Xin-Nao-Kang Capsule, a traditional Chinese medicinal formula, by UHPLC-Q-TOF-MS and UHPLC-TQ-MS."J Pharmaceut Biomed. 2021 May;198:114002 102. [IF=3.882] Kunpeng Yin et al."Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine."Langmuir. 2021;37(17):5321–5328 103. [IF=3.361] Mengmeng Yuan et al."The interaction of dietary flavonoids with xanthine oxidase in vitro: molecular property-binding affinity relationship aspects."Rsc Adv. 2019 Apr;9(19):10781-10788 104. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 105. [IF=2.877] Wanli Ji et al."Identifying the active compounds and mechanism of action of Banxia Xiexin decoction for treating ethanol-induced chronic gastritis using network pharmacology combined with UPLC–LTQ–Orbitrap MS."Comput Biol Chem. 2021 Aug;93:107535 106. [IF=2.193] Xu Tong et al."A Preferable Approach for the Quality Control of Xiaoer Chiqiao Qingre Granules Based on the Combination of Chromatographic Fingerprints and Chemometrics."J Anal Methods Chem. 2020;2020:6836981 107. [IF=2.193] Xue Gen et al."Integrating Study on Qualitative and Quantitative Characterization of the Major Constituents in Shuanghuanglian Injection with UHPLC/Q-Orbitrap-MS and UPLC-PDA."J Anal Methods Chem. 2021;2021:9991363 108. [IF=1.913] Zheng XP et al."Kidney-targeted baicalin-lysozyme conjugate ameliorates renal fibrosis in rats with diabetic nephropathy induced by streptozotocin.."Bmc Nephrol. 2020 May;21(1):174-174 109. [IF=1.851] Rui Li et al."Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a."Mol Med Rep. 2019 Dec;20(6):5041-5049 110. [IF=1.625] Hong-Jing Sun et al."Baicalin Alleviates Age-Related Macular Degeneration via miR-223/NLRP3-Regulated Pyroptosis."Pharmacology. 2020;105(1-2):28-38 111. [IF=4.36] Jiali Zhou et al.The root extract of Scutellaria baicalensis Georgi promotes β cell function and protects from apoptosis by inducing autophagy.J Ethnopharmacol. 2022 Feb;284:114790 112. [IF=2.193] Zhang Haibo et al.Systematic Study on a Quantitative Analysis of Multicomponents by Single Marker (QAMS) Method for Simultaneous Determination of Eight Constituents in Pneumonia Mixture by UPLC-MS/MS.J Anal Methods Chem. 2021;2021:8311588 113. [IF=3.205] Wanli Ji et al."Revealing therapeutic targets and mechanism of baicalin for anti-chronic gastritis using proteomic analysis of the gastric tissue."J Chromatogr B. 2022 Mar;:123214 114. [IF=4.072] He Pang et al."Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and β-catenin signaling pathways."J Bone Oncol. 2022 Apr;33:100415 115. [IF=5.095] Liu Fengjie et al."Baicalin-loaded folic acid-modified albumin nanoparticles (FA-BSANPs/BA) induce autophagy in MCF-7 cells via ROS-mediated p38 MAPK and Akt/mTOR pathway."Cancer Nanotechnol. 2022 Dec;13(1):1-21 116. [IF=3.935] Yizhu Wang et al."Effects of Scutellaria baicalensis Georgi. on Intestinal Flora in Rats with Spleen Deficiency and Damp-heat."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2022 May;:114831 |
黄芩甙 - 介绍
药理药效：具有广谱抗菌作用,还有利胆、抗炎、抗变态反应、解热、解毒、利尿、降压等作用。临床上用于治疗传染性肝炎,对降低肝炎活动期中谷丙转氨酶有较好疗效,还用叶于治疗中风和瘫痪，可降低脑血管阻力，增加脑血流量，提高血脑屏障通透性及对抗由磷酸腺苷引起的血小板凝集作用。
最后更新：2022-10-16 17:15:00
黄芩甙 - 简介
黄芩甙是一种草药成分，常见于黄芩（学名：Scutellaria baicalensis）。它具有以下性质：
化学性质：黄芩甙是一种呈黄色结晶固体，可溶于水和乙醇。它属于黄酮类化合物，其主要成分为黄芩苷（baicalin）和黄芩素（baicalein）。
药理作用：黄芩甙具有抗炎、抗菌、抗氧化、抗肿瘤、清热解毒等药理作用。它常被用于中药治疗感染性疾病、肝炎、胃溃疡、心脑血管疾病等。
制法：黄芩甙的制法一般是通过提取黄芩的根茎部位，然后经过浓缩、结晶等工艺步骤获得。一些生产厂家也会采用现代提取技术，如超临界流体萃取法，以提高提取效率。
安全信息：黄芩甙是一种天然植物成分，通常被认为是相对安全的。在使用过程中，应遵循正确的剂量和使用方法，避免过量使用或长期使用可能会引起的不良反应。如发生任何不适，应立即停止使用并咨询医生。
化学性质：黄芩甙是一种呈黄色结晶固体，可溶于水和乙醇。它属于黄酮类化合物，其主要成分为黄芩苷（baicalin）和黄芩素（baicalein）。
药理作用：黄芩甙具有抗炎、抗菌、抗氧化、抗肿瘤、清热解毒等药理作用。它常被用于中药治疗感染性疾病、肝炎、胃溃疡、心脑血管疾病等。
制法：黄芩甙的制法一般是通过提取黄芩的根茎部位，然后经过浓缩、结晶等工艺步骤获得。一些生产厂家也会采用现代提取技术，如超临界流体萃取法，以提高提取效率。
安全信息：黄芩甙是一种天然植物成分，通常被认为是相对安全的。在使用过程中，应遵循正确的剂量和使用方法，避免过量使用或长期使用可能会引起的不良反应。如发生任何不适，应立即停止使用并咨询医生。
最后更新：2024-04-09 15:16:48
供应商列表
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产品名: 黄芩苷 去供应商网站查看 询盘CAS: 21967-41-9
产地: 上海
包装: 1ml,100g,25g,200mg,1g,5g,500g,100g,1g,25g,5g,100mg,50mg,10mg
规格: B762066
价格: 260,6196,2813,62,203,939,1868,397,43,155,70,1903,1213,388
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2881510266
微信: 19863730987/17821173903
提供多种规格现货供应
产品名: 黄芩苷(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IB00101
产地: 北京
包装: 1ml/瓶
规格: IB00101-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 18101056239(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 18101056239
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
主打产品现货供应
产品名: 黄芩苷 去供应商网站查看 询盘CAS: 21967-41-9
产地: 上海
包装: 1ml,100g,25g,200mg,1g,5g,500g,100g,1g,25g,5g,100mg,50mg,10mg
规格: B762066
价格: 260,6196,2813,62,203,939,1868,397,43,155,70,1903,1213,388
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2881510266
微信: 19863730987/17821173903
提供多种规格现货供应
产品名: 黄芩苷(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IB00101
产地: 北京
包装: 1ml/瓶
规格: IB00101-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 18101056239(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 18101056239
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
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