(S)-1-Boc-3-hydroxymethylpiperazine
(S)-1-Boc-3-hydroxymethylpiperazine
CAS: 314741-40-7
Molecular Formula: C10H20N2O3
(S)-1-Boc-3-hydroxymethylpiperazine - Names and Identifiers
(S)-1-Boc-3-hydroxymethylpiperazine - Physico-chemical Properties
| Molecular Formula | C10H20N2O3 |
| Molar Mass | 216.28 |
| Density | 1.085±0.06 g/cm3(Predicted) |
| Boling Point | 322.9±22.0 °C(Predicted) |
| Flash Point | 149.1°C |
| Vapor Presure | 2.15E-05mmHg at 25°C |
| pKa | 14.97±0.10(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | 1.477 |
(S)-1-Boc-3-hydroxymethylpiperazine - Reference Information
| use | (S)-1-BOC-3-hydroxymethylpiperazine is an organic synthesis intermediate and a pharmaceutical intermediate, which can be used in laboratory research and development processes and chemical and pharmaceutical synthesis processes. |
| Preparation | Add (S)-(4-benzylpiperazine -2-yl) methanol (15K)(10.3g,50mmol) and methanol (100mL) to a 200mL round bottom flask. add carbon-loaded palladium hydroxide (3.0g) and circulate the flask with hydrogen and vacuum five times. The flask was stirred overnight with atmospheric hydrogen at room temperature. The reaction was filtered through diatomite with a Brinell funnel. Cool the filtrate to -15°C. Boc anhydride (10.9g, 1 eq) was slowly added to the methanol solution. When the addition is complete, heat the flask to 0°C and stir for 2 hours. Heat the flask to room temperature and remove the solvent under vacuum. The residue was purified by column chromatography using 4:2 ethyl acetate methanol to obtain 15L of oil (11.01g,85%). |
Last Update：2024-04-09 20:52:54
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View History
(S)-1-Boc-3-hydroxymethylpiperazine
3-(Trifluoromethyl)phenylhydrazine hydrochloride
Bromo(2,5-dimethylphenyl)magnesium
2-tert-Butyl-4,6-dimethylphenol
5-溴-2-甲基-2,3-二氢-1H-茚-1-酮
1-Boc-4-[甲氧基(甲基)氨基甲酰基]哌啶
3-(Trifluoromethyl)phenylhydrazine hydrochloride
Bromo(2,5-dimethylphenyl)magnesium
2-tert-Butyl-4,6-dimethylphenol
5-溴-2-甲基-2,3-二氢-1H-茚-1-酮
1-Boc-4-[甲氧基(甲基)氨基甲酰基]哌啶