(S)-N-BOC-3-Chlorophenylalanine
(S)-N-BOC-3-Chlorophenylalanine
CAS: 114873-03-9
Molecular Formula: C14H18ClNO4
(S)-N-BOC-3-Chlorophenylalanine - Names and Identifiers
| Name | (S)-N-BOC-3-Chlorophenylalanine |
| Synonyms | RARECHEM BK PT 0008 Boc-L-3-Chlorophenylalanine Boc-3-Chloro-L-phenylalanine (S)-N-BOC-3-Chlorophenylalanine 3-Chloro-L-phenylalanine, N-BOC protected N-TERT-BUTOXYCARBONYL-L-3-CHLORO PHENYLALANINE N-ALPHA-TERT-BUTYLOXYCARBONYL-3-CHLORO-L-PHENYLALANINE 3-chloro-n-[(1,1-dimethylethoxy)carbonyl]-l-phenylalanine (S)-2-(tert-butoxycarbonylamino)-3-(3-chlorophenyl)propanoic acid (S)-2-TERT-BUTOXYCARBONYLAMINO-3-(3-CHLORO-PHENYL)-PROPIONIC ACID |
| CAS | 114873-03-9 |
| InChI | InChI=1/C14H18ClNO4/c1-14(2,3)20-13(19)16-11(12(17)18)8-9-5-4-6-10(15)7-9/h4-7,11H,8H2,1-3H3,(H,16,19)(H,17,18)/t11-/m0/s1 |
(S)-N-BOC-3-Chlorophenylalanine - Physico-chemical Properties
| Molecular Formula | C14H18ClNO4 |
| Molar Mass | 299.75 |
| Density | 1.245 |
| Melting Point | 110°C |
| Boling Point | 452.5±40.0 °C(Predicted) |
| Flash Point | 227.5°C |
| Vapor Presure | 5.61E-09mmHg at 25°C |
| pKa | 3.81±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.538 |
| Physical and Chemical Properties | Density 1.245 melting point 110°C |
(S)-N-BOC-3-Chlorophenylalanine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| Hazard Class | IRRITANT |
(S)-N-BOC-3-Chlorophenylalanine - Introduction
N-tert-Butoxycarbonyl-L-3-chlorophenylalanine (also known as N-Boc-L-3-chlorophenylalanine) is a chemical substance that has the following properties:
1. Appearance: White crystalline solid.
2. Solubility: Soluble in some organic solvents, such as dimethylformamide (DMF) and dichloromethane.
3. molecular formula: C13H17ClNO4.
4. Molecular weight: 273.73g/mol.
5. melting point: about 50-55 degrees Celsius.
N-tert-butoxycarbonyl-L-3-chlorophenylalanine is mainly used in chemical synthesis and drug research. The specific uses are as follows:
1. As a synthetic drug intermediate: It can be used to synthesize biologically active compounds, especially for the synthesis of drugs with amino acid structure.
2. drug research: it can be used to study the properties, activity and pharmacokinetics of drugs.
The preparation method of N-tert-butoxycarbonyl-L-3-chlorophenylalanine mainly includes the following steps:
1. Reaction of N-tert-butyl-3-chlorophenpropylamine with dichloromethane to generate N-tert-butyl-3-chlorophenyl propyl isocyanate (also known as N-Boc-L-3-chlorophenyl propyl isocyanate).
2. heating reaction of N-Boc-L-3-chlorophenylpropyl isocyanate and sodium acetate in methanol to generate N-Boc-L-3-chlorophenylalanine.
For safety information on N-tert-butoxycarbonyl-L-3-chlorophenylalanine, there are the following precautions:
1. use the need to wear protective glasses and gloves, to ensure adequate ventilation.
2. Avoid inhaling dust or contact with skin. In case of contact, rinse immediately with plenty of water and seek medical help.
3. storage should be sealed, away from fire and oxidant, avoid high temperature and humid environment.
4. for those who cannot be used or handled correctly, it is recommended to consult the guidance of professionals.
Summary: N-tert-butoxycarbonyl-L-3-chlorophenylalanine is an organic compound, mainly used in chemical synthesis and pharmaceutical research. Pay attention to safety when using, avoid inhalation and contact.
1. Appearance: White crystalline solid.
2. Solubility: Soluble in some organic solvents, such as dimethylformamide (DMF) and dichloromethane.
3. molecular formula: C13H17ClNO4.
4. Molecular weight: 273.73g/mol.
5. melting point: about 50-55 degrees Celsius.
N-tert-butoxycarbonyl-L-3-chlorophenylalanine is mainly used in chemical synthesis and drug research. The specific uses are as follows:
1. As a synthetic drug intermediate: It can be used to synthesize biologically active compounds, especially for the synthesis of drugs with amino acid structure.
2. drug research: it can be used to study the properties, activity and pharmacokinetics of drugs.
The preparation method of N-tert-butoxycarbonyl-L-3-chlorophenylalanine mainly includes the following steps:
1. Reaction of N-tert-butyl-3-chlorophenpropylamine with dichloromethane to generate N-tert-butyl-3-chlorophenyl propyl isocyanate (also known as N-Boc-L-3-chlorophenyl propyl isocyanate).
2. heating reaction of N-Boc-L-3-chlorophenylpropyl isocyanate and sodium acetate in methanol to generate N-Boc-L-3-chlorophenylalanine.
For safety information on N-tert-butoxycarbonyl-L-3-chlorophenylalanine, there are the following precautions:
1. use the need to wear protective glasses and gloves, to ensure adequate ventilation.
2. Avoid inhaling dust or contact with skin. In case of contact, rinse immediately with plenty of water and seek medical help.
3. storage should be sealed, away from fire and oxidant, avoid high temperature and humid environment.
4. for those who cannot be used or handled correctly, it is recommended to consult the guidance of professionals.
Summary: N-tert-butoxycarbonyl-L-3-chlorophenylalanine is an organic compound, mainly used in chemical synthesis and pharmaceutical research. Pay attention to safety when using, avoid inhalation and contact.
Last Update：2024-04-09 21:54:55
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CAS: 114873-03-9
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View History
(S)-N-BOC-3-Chlorophenylalanine
1-methyl-piperazin
1,3-dichloro acetone
水杨酸苄酯 标准品
Tris(sec-butyl)borane
SodiuM hexacyanoferrate(III)
2-Oxyisovaleric acid ethyl ester
(S)-螺环二酸
1,1-difluoroethane
Nα-Boc-L-tryptophan
1-methyl-piperazin
1,3-dichloro acetone
水杨酸苄酯 标准品
Tris(sec-butyl)borane
SodiuM hexacyanoferrate(III)
2-Oxyisovaleric acid ethyl ester
(S)-螺环二酸
1,1-difluoroethane
Nα-Boc-L-tryptophan