1-(2-Tetrahydropyranyl)-1...

1-(2-Tetrahydropyranyl)-1... - Names and Identifiers

Name	1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester
Synonyms	1-(2-Tetrahydropyranyl)-1... 1-(tetrahydro-2H-pyran-2-yl)-4-(4 1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester 1-(oxan-2-yl)-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-boronic acid, pinacol ester 1-Tetrahydropyran-2-yl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyrazole 1-(Tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1-(tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CAS	1003846-21-6
InChI	InChI=1S/C14H23BN2O3/c1-13(2)14(3,4)20-15(19-13)11-9-16-17(10-11)12-7-5-6-8-18-12/h9-10,12H,5-8H2,1-4H3
InChIKey	YYSLAWXDXHVRHU-UHFFFAOYSA-N

1-(2-Tetrahydropyranyl)-1... - Physico-chemical Properties

Molecular Formula	C14H23BN2O3
Molar Mass	278.15
Density	1.16±0.1 g/cm3(Predicted)
Boling Point	413.8±35.0 °C(Predicted)
pKa	1.95±0.19(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature

1-(2-Tetrahydropyranyl)-1... - Reference Information

Application

1-THP-4-pyrazole borate pinacol ester has considerable prospects as a pharmaceutical intermediate and pesticide intermediate.

Preparation

About the synthesis of 3-chloro-5-trifluoromethyl-1-methylpyrazol-4-boric acid, under the action of a palladium catalyst, In the presence of triethylamine, 4-iodopyrazole and borate pinacol can undergo a coupling reaction to form 1H-pyrazol-4-borate pinacol. It was oxidized in 3, 4-dihydro-2H-pyran to prepare 1-THP-4-pyrazole borate pinacol ester. The reaction equation is as follows: Figure 1 1-THP-4-pyrazole boric acid pinacol ester reaction equation

Last Update：2024-04-09 21:32:03