Molecular Formula | C27H29ClN6O2 |
Molar Mass | 505.01 |
Density | 1.34±0.1 g/cm3(Predicted) |
Boling Point | 631.2±55.0 °C(Predicted) |
pKa | 11.82±0.70(Predicted) |
Storage Condition | 2-8°C |
In vitro study | Y-320 murine CD4 T cells stimulated by IL-15, CXCL12, and anti-CD3 mAb also inhibited IFN-γ and TNF-α production. Y-320 murine CD4 T cells stimulated by IL-15, CXCL12, and anti-CD3 mAb also inhibited IFN-γ and TNF-α production. |
In vivo study | Y-320 (0.3-3 mg/kg, P. O.) improves collagen-induced arthritis (CIA) in mice, reduces IL-17 mRNA in arthritic joints, and exhibits therapeutic effects on CIA in rhesus monkeys. In addition, Y-320 combined with anti-TNF-α mAb showed a synergistic effect on chronic CIA in mice. Y-320 (0.3-3 mg/kg, P. O.) improves collagen-induced arthritis (CIA) in mice, reduces IL-17 mRNA in arthritic joints, and in rhesus monkeys showed therapeutic effect on CIA. In addition, Y-320 combined with anti-TNF-α mAb showed a synergistic effect on chronic CIA in mice. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.98 ml | 9.901 ml | 19.802 ml |
5 mM | 0.396 ml | 1.98 ml | 3.96 ml |
10 mM | 0.198 ml | 0.99 ml | 1.98 ml |
5 mM | 0.04 ml | 0.198 ml | 0.396 ml |