1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine

1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine - Names and Identifiers

Name	1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine
Synonyms	N-Boc-3-methanesulfonyloxyazetidine 1-Boc-3-methanesulfonyloxy-azetidine 1-Boc-3-(methanesulfonyloxy)azetidine 1-(tert-butoxycarbonyl)azetidine-3-carboxylic acid 1-(tert-butoxycarbonyl)azetidine-3-yl-methanesulfonate 1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine tert-Butyl 3-[(methylsulfonyl)oxy]azetane-1-carboxylate tert-Butyl 3-[(methylsulfonyl)oxy]-1-azetidinecarboxylate tert-butyl 3-[(methylsulfonyl)oxy]azetidine-1-carboxylate 3-((Methylsulfonyl)oxy)azetidine-1-carboxylic acid tert-butyl ester 3-[(Methanesulfonyl)oxy]azetidine-1-carboxylic acid tert-butyl ester
CAS	141699-58-3
InChI	InChI=1/C9H17NO5S/c1-9(2,3)14-8(11)10-5-7(6-10)15-16(4,12)13/h7H,5-6H2,1-4H3

1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine - Physico-chemical Properties

Molecular Formula	C9H17NO5S
Molar Mass	251.3
Density	1.28±0.1 g/cm3(Predicted)
Melting Point	69 °C
Boling Point	378.5±31.0 °C(Predicted)
Flash Point	182.731°C
Vapor Presure	0mmHg at 25°C
Appearance	powder to crystal
Color	White to Light yellow
pKa	-4.18±0.40(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.504

1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine - Risk and Safety

Hazard Symbols	T - Toxic
Risk Codes	25 - Toxic if swallowed
Safety Description	45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2811 6.1 / PGIII
Hazard Class	IRRITANT

1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine - Introduction

1-Boc-3-(methylsulfonyloxy) azetidine is an organic compound with the chemical name (S)-Boc-3-(methylsulfonyloxy)pentan-1-amine. It is a white solid, stable at room temperature. The compound has a certain solubility, soluble in some organic solvents, such as dichloromethane and ethanol. It is a strong basic functional group, which can be removed by deprotection reaction under acidic conditions.

1-Boc-3-(methylsulfonyloxy) azetidine is widely used as an intermediate in organic synthesis. It can generate various functional compounds by substitution reaction, condensation reaction and amination reaction. One important use is in the synthesis of drugs. For example, an anticancer drug can be synthesized by a substitution reaction of 1-Boc-3-(methylsulfonyloxy) azetidine.

1-Boc-3-(methanesulfonyloxy) azetidine is generally prepared by reacting 3-hydroxyazetidine with methanesulfonyl chloride to obtain a methanesulfonylated product, which is then subjected to a condensation reaction with a Boc-protecting agent to obtain the target product.

However, note the safety information for this compound. When using the need to pay attention to protective measures, such as wearing gloves, protective glasses and protective clothing. Avoid inhalation, ingestion or contact with skin and eyes as it may be irritating to the skin and eyes. In addition, it should be stored in a dry place, away from fire and oxidizing agents.

Last Update：2024-04-09 20:52:54