1-AMINO-3,6,9-TRIOXAUNDECANYL-11-OL
1-AMINO-3,6,9-TRIOXAUNDECANYL-11-OL
CAS: 86770-74-3
Molecular Formula: C8H19NO4
1-AMINO-3,6,9-TRIOXAUNDECANYL-11-OL - Names and Identifiers
1-AMINO-3,6,9-TRIOXAUNDECANYL-11-OL - Physico-chemical Properties
| Molecular Formula | C8H19NO4 |
| Molar Mass | 193.24 |
| Density | 1.068±0.06 g/cm3(Predicted) |
| Boling Point | 301.6±27.0 °C(Predicted) |
| Solubility | Soluble in chloroform, dichloromethane, ethyl acetate and methanol |
| Appearance | solid or viscous liquid |
| Color | Colourless to Dark Brown |
| pKa | 14.36±0.10(Predicted) |
| Storage Condition | -20°C |
| Sensitive | Easily absorbing moisture |
| Physical and Chemical Properties | Bioactive Amino-PEG4-alcohol is a PEG-based PROTAC linker that can be used to synthesize PROTAC. Amino-PEG4-alcohol is also a non-cleavable ADC linker for the synthesis of antibody-coupled drugs (ADC). |
| Use | Use 1-amino -3,6,9-trioxo -11-11 alcohol can be used to prepare a PROTAC compound targeting IDO1 degradation. |
1-AMINO-3,6,9-TRIOXAUNDECANYL-11-OL - Upstream Downstream Industry
1-AMINO-3,6,9-TRIOXAUNDECANYL-11-OL - Uses and synthesis methods
Introduction
1-amino -3,6, 9-triox-11-undiol is an alcohol derivative and can be used as a pharmaceutical intermediate.
Preparation
1-Amino -3,6, 9-Trioxo-11-11-11-11-alcohol can be prepared from triethylene glycol through a three-step reaction.
Target
PEGs
Non-cleavable
in vitro studies
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Last Update：2024-04-10 22:29:15
1-AMINO-3,6,9-TRIOXAUNDECANYL-11-OL - Nature
| EPA chemical information | Ethanol, 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]- (86770-74-3) |
Last Update：2024-04-09 21:04:16
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View History
Raw Materials for 1-AMINO-3,6,9-TRIOXAUNDECANYL-11-OL
1H-Isoindole-1,3(2H)-dione, 2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]-
1-METHANESULFONYL-11-HYDROXY-3,6,9-TRIOXAUNDECANE
2,5,8,11-Tetraoxatridecan-13-ol, 1,1,1-triphenyl-
2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol
N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL
1-METHANESULFONYL-11-HYDROXY-3,6,9-TRIOXAUNDECANE
2,5,8,11-Tetraoxatridecan-13-ol, 1,1,1-triphenyl-
2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol
N-BOC-AMINOEHTOXY-ETHOXY-ETHOXY-ETHANOL