1-Chloro-2-propanol
1-Chloro-2-propanol
CAS: 127-00-4
Molecular Formula: C3H7ClO
1-Chloro-2-propanol - Names and Identifiers
1-Chloro-2-propanol - Physico-chemical Properties
| Molecular Formula | C3H7ClO |
| Molar Mass | 94.54 |
| Density | 1.111g/mLat 25°C(lit.) |
| Boling Point | 126-127°C(lit.) |
| Flash Point | 125°F |
| Water Solubility | Soluble in water |
| Vapor Presure | 14.384mmHg at 25°C |
| Appearance | clear liquid |
| Color | Colorless to Light yellow |
| Exposure Limit | ACGIH: TWA 1 ppm (Skin) |
| Merck | 14,7851 |
| BRN | 773653 |
| pKa | 14.09±0.20(Predicted) |
| Storage Condition | Flammables area |
| Stability | Stable. Flammable. Incompatible with strong oxidizing agents. |
| Refractive Index | n20/D 1.439(lit.) |
| Physical and Chemical Properties | Colorless liquid with slightly ether odor. Boiling point 127.4 ℃,46-50 ℃(4.0kPa), relative density 1.115(20/20 ℃), refractive index 1.4394. Flash point (Open Cup) 51.5 ℃, viscosity (20 ℃)4.67mPa · s, surface tension 32.1mN/m. Soluble in water, ethanol. |
| Use | Mainly used for the production of propylene oxide, medicine for the synthesis of chlorpromazine |
1-Chloro-2-propanol - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R10 - Flammable R20 - Harmful by inhalation R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/39 - |
| UN IDs | UN 2611 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | UA8942000 |
| FLUKA BRAND F CODES | 19 |
| TSCA | Yes |
| HS Code | 29055900 |
| Hazard Class | 6.1 |
| Packing Group | II |
1-Chloro-2-propanol - Nature
Open Data Verified Data
colorless liquid with slightly ether odor. Boiling point 127.4 °c. Flash point (Open Cup) 51.5 °c. Viscosity (20 ℃)4. 67MPA. s. Density 1.11 32g/cm3. Surface tension 32. 1mN/m. Refractive index 4394. Soluble in water, ethanol.
Last Update：2025-06-10 22:55:16
1-Chloro-2-propanol - Preparation Method
Open Data Verified Data
- The propylene hypochlorous acid method is mainly composed of propylene and hypochlorous acid at 45~60 C, atmospheric pressure (about 0.12~0. The addition reaction was carried out under 13MPa), and the reaction solution was neutralized and distilled to obtain a finished product.
- propylene oxide monochloride method
- allyl chloride-sulfuric acid method
Last Update：2022-01-01 10:15:39
1-Chloro-2-propanol - Application
Open Data Verified Data
manufacture of propylene oxide and propylene glycol intermediates, widely used in polyurethane and other unsaturated polyester resin production. Medicinal for the synthesis of chlorpromazine.
Last Update：2025-08-19 16:24:40
1-Chloro-2-propanol - Safety
Open Data Verified Data
- toxic. Inhalation of high concentrations of internal organs and nervous system damage, serious fatal. Rat LC5O.08g/m3. The maximum allowable concentration in the air of workplace l6mg/m3. When handling and using, it is advisable to wear neoprene gloves, protective clothing and masks to prevent inhalation or absorption through the skin.
- can react with a variety of metals, and therefore should be stored in glass or ceramic lined carbon steel containers to prevent contamination and discoloration. Flammable and can be decomposed into highly toxic phosgene, and therefore should not be exposed to open flame. According to the provisions of flammable and toxic chemicals storage and transportation.
Last Update：2022-01-01 10:15:40
1-Chloro-2-propanol - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | organic synthesis intermediates. Mainly used in the manufacture of propylene oxide and propylene glycol. It is widely used in the production of polyurethane and other unsaturated polyester resins. Medicinal for the synthesis of chlorpromazine. mainly used in the production of propylene oxide, medicine for the synthesis of chlorpromazine |
| production method | (1) is derived from the hypochlorous esterification of propylene. Propylene, chlorine and water are passed into the hypochlorous acid reaction Tower according to a certain ratio. Generally, when there is no free chlorine in the reaction liquid and tail gas due to excessive propylene and the concentration of chlorohydrin in the reaction liquid is less than 5%, the selectivity of chloropropanol was 90%. The tail gas is partially vented after water washing and alkali washing to prevent accumulation of inert gas, and the remainder is mixed with fresh propylene after compression and returned to the reaction system. In the reaction at a reaction column temperature of 45 to 60 ° C., about 0.12 to 0.13MPA and an excess of propylene, The propylene conversion was 97%. Of these, 93.5% is chloropropanol, 4.5% is dichloropropane, 1.7% is 2.2 '-dichlorodiisopropyl ether, and 0.3% is propionaldehyde, acetone and other by-products. In the obtained chloropropanol, 1-chloro-2-propanol was about 90%, and 2-chloropropanol was about 10%. (2) by the role of allyl chloride and sulfuric acid derived. At low temperature, sulfuric acid was added dropwise to allyl chloride and the reaction was stirred. The reaction solution was slowly added to ice water, and then subjected to distillation to obtain a finished product with a yield of 86.5%. In addition, 1-chloro-2-propanol can also be obtained by reacting propylene oxide with hydrogen chloride. |
| category | toxic substances |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50 300 mg/kg; Oral-mouse LD50: 220 mg/kg |
| flammability hazard characteristics | open flame, high heat flammable; Thermal decomposition releases toxic chloride gas; reaction with oxidant |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature, separate storage of food additives |
| extinguishing agent | dry powder, foam, carbon dioxide, sand |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:41:03
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View History
1-Chloro-2-propanol
63307-81-3
5407-91-0
1076-74-0
Mountain degree of drug
18952-87-9
104-53-0
320-42-3
97659-47-7
63307-81-3
5407-91-0
1076-74-0
Mountain degree of drug
18952-87-9
104-53-0
320-42-3
97659-47-7