1003845-06-4
2-Chloropyrimidine-5-Boronic Acid
CAS: 1003845-06-4
Molecular Formula: C4H4BClN2O2
1003845-06-4 - Names and Identifiers
1003845-06-4 - Physico-chemical Properties
| Molecular Formula | C4H4BClN2O2 |
| Molar Mass | 158.35 |
| Density | 1.52±0.1 g/cm3(Predicted) |
| Boling Point | 425.4±37.0 °C(Predicted) |
| Appearance | Powder |
| Color | White |
| pKa | 5.03±0.11(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| MDL | MFCD08063113 |
1003845-06-4 - Introduction
2-chloropyrimidine-5-boronic acid (acid) is an organic compound with the chemical formula C4H4BClN2O2.
Nature:
2-chloropyrimidine-5-boronic acid is a colorless solid and can be dissolved in some organic solvents such as dimethyl sulfoxide, dichloromethane, etc. It is an important boric acid compound with high chemical stability.
Use:
2-chloropyrimidine-5-boronic acid is commonly used in organic synthesis as an organic heavy raw material, which can be used to synthesize compounds with important physiological activities. Among them, 2-chloropyrimidine group can undergo Suzuki coupling reaction and react with compounds containing active aryl groups to synthesize various derivatives, which are commonly used in drug synthesis, pesticide synthesis and other organic synthesis fields.
Preparation Method:
The preparation of 2-chloropyrimidine-5-boronic acid is often carried out by reacting 2-chloropyrimidine and boric acid. In general, 2-chloropyrimidine is first reacted with an alkaline substrate (e. g., sodium carbonate) to form the corresponding negative halide ion, which is then reacted with boric acid to give the desired product.
Safety Information:
2-chloropyrimidine -5-boric acid has a certain irritating effect on the eyes, skin and respiratory system. Wear suitable protective gloves, goggles and breathing apparatus to avoid contact with and inhalation of the compound during operation. During storage, keep away from heat sources, fire sources and oxidants to avoid fire or explosion.
Nature:
2-chloropyrimidine-5-boronic acid is a colorless solid and can be dissolved in some organic solvents such as dimethyl sulfoxide, dichloromethane, etc. It is an important boric acid compound with high chemical stability.
Use:
2-chloropyrimidine-5-boronic acid is commonly used in organic synthesis as an organic heavy raw material, which can be used to synthesize compounds with important physiological activities. Among them, 2-chloropyrimidine group can undergo Suzuki coupling reaction and react with compounds containing active aryl groups to synthesize various derivatives, which are commonly used in drug synthesis, pesticide synthesis and other organic synthesis fields.
Preparation Method:
The preparation of 2-chloropyrimidine-5-boronic acid is often carried out by reacting 2-chloropyrimidine and boric acid. In general, 2-chloropyrimidine is first reacted with an alkaline substrate (e. g., sodium carbonate) to form the corresponding negative halide ion, which is then reacted with boric acid to give the desired product.
Safety Information:
2-chloropyrimidine -5-boric acid has a certain irritating effect on the eyes, skin and respiratory system. Wear suitable protective gloves, goggles and breathing apparatus to avoid contact with and inhalation of the compound during operation. During storage, keep away from heat sources, fire sources and oxidants to avoid fire or explosion.
Last Update：2024-04-09 02:00:40
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