1005491-05-3
Tirasemtiv
CAS: 1005491-05-3
Molecular Formula: C12H14N4O
1005491-05-3 - Names and Identifiers
1005491-05-3 - Physico-chemical Properties
| Molecular Formula | C12H14N4O |
| Molar Mass | 230.27 |
| Melting Point | >130°C (dec.) |
| Solubility | DMSO: ≥ 52 mg/mL |
| Appearance | Morphological Solid |
| Color | Beige to Brown |
| Storage Condition | -20°C Freezer |
| Physical and Chemical Properties | Bioactive Tirasemtiv (CK-2017357, CK-357) is a direct fast skeletal muscle troponin activator, which can make sarcomere sensitive to calcium. |
| Use | Tirasemtiv is a fast skeletal muscle-type troponin complex activator. |
1005491-05-3 - Reference
| Reference Show more | 1: Sanders DB, Rosenfeld J, Dimachkie MM, Meng L, Malik FI; Tirasemtiv in Myasthenia Gravis Study Group. A Double-Blinded, Randomized, Placebo-Controlled Trial to Evaluate Efficacy, Safety, and Tolerability of Single Doses of Tirasemtiv in Patients with Acetylcholine Receptor-Binding Antibody-Positive Myasthenia Gravis. Neurotherapeutics. 2015 Apr;12(2):455-60. doi: 10.1007/s13311-015-0345-y. PubMed PMID: 25742919; PubMed Central PMCID: PMC4404445. 2: Bauer TA, Wolff AA, Hirsch AT, Meng LL, Rogers K, Malik FI, Hiatt WR. Effect of tirasemtiv, a selective activator of the fast skeletal muscle troponin complex, in patients with peripheral artery disease. Vasc Med. 2014 May 28;19(4):297-306. [Epub ahead of print] PubMed PMID: 24872402. 3: Hwee DT, Kennedy A, Ryans J, Russell AJ, Jia Z, Hinken AC, Morgans DJ, Malik FI, Jasper JR. Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model. PLoS One. 2014 May 7;9(5):e96921. doi: 10.1371/journal.pone.0096921. eCollection 2014. PubMed PMID: 24805850; PubMed Central PMCID: PMC4013064. 4: Hansen R, Saikali KG, Chou W, Russell AJ, Chen MM, Vijayakumar V, Stoltz RR, Baudry S, Enoka RM, Morgans DJ, Wolff AA, Malik FI. Tirasemtiv amplifies skeletal muscle response to nerve activation in humans. Muscle Nerve. 2014 Dec;50(6):925-31. doi: 10.1002/mus.24239. PubMed PMID: 24634285; PubMed Central PMCID: PMC4260123. |
1005491-05-3 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.343 ml | 21.714 ml | 43.428 ml |
| 5 mM | 0.869 ml | 4.343 ml | 8.686 ml |
| 10 mM | 0.434 ml | 2.171 ml | 4.343 ml |
| 5 mM | 0.087 ml | 0.434 ml | 0.869 ml |
Last Update：2024-01-02 23:10:35
1005491-05-3 - Reference Information
| biological activity | Tirasemtiv (CK-2017357, CK-357) is a direct fast skeletal muscle troponin activator, which can make sarcomere sensitive to calcium. |
| target | TargetValue Troponin () |
| Target | Value |
Last Update：2024-04-09 21:11:58
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Product Name: CK-2017357 Visit Supplier Webpage Request for quotationCAS: 1005491-05-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
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Product Name: Tirasemtiv Visit Supplier Webpage Request for quotationCAS: 1005491-05-3
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