100750-05-8
Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
CAS: 100750-05-8;126727-04-6
Molecular Formula: C24H21NO4
100750-05-8 - Names and Identifiers
100750-05-8 - Physico-chemical Properties
| Molecular Formula | C24H21NO4 |
| Molar Mass | 387.43 |
| Storage Condition | 2-8℃ |
100750-05-8 - Reference
| Reference Show more | 1. [IF=9.776] Jinsong Shao et al.Erythrocyte-mimicking subcutaneous platform with a laser-controlled treatment against diabetes.J Control Release. 2022 Jan;341:261 |
100750-05-8 - Introduction
FMOC-DL-Phenylalanine is a commonly used compound for protecting amino acids. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White crystalline solid
-Molecular formula: C23H23NO5
-Molecular weight: 397.43g/mol
-Melting point: 159-162°C
-Solubility: insoluble in water, soluble in organic solvents such as dichloromethane, ethyl acetate
Use:
FMOC-DL-Phenylalanine is commonly used in solid-phase synthesis, peptide chemistry, and protein research. It is a commonly used amino acid protecting agent that can protect the amine group without affecting the reaction of other functional groups. When the peptide chain is synthesized, it can be used as a protective agent for the amino acid unit, protecting the amine group, and removing it when necessary, so that it can participate in the extension reaction of the peptide chain. It can also be used as an important intermediate in pharmaceutical research and synthetic chemistry.
Preparation Method:
A common preparation method is to react DL-phenylalanine with FMOC-OSu (9-fluorothiocarbyl chloride) under base catalysis to generate FMOC-DL-phenylalanine.
Safety Information:
FMOC-DL-phenylalanine has no obvious danger under correct operation. However, it is a chemical, and the following safety precautions should be paid attention:
-Avoid direct contact with skin and eyes, and avoid inhaling dust or gas.
-Wear appropriate safety gloves, goggles and overalls during operation.
-If contact or ingestion occurs, immediately rinse the affected area with plenty of water and seek medical help.
-Follow proper laboratory practices and safe operating procedures during storage and handling.
Nature:
-Appearance: White crystalline solid
-Molecular formula: C23H23NO5
-Molecular weight: 397.43g/mol
-Melting point: 159-162°C
-Solubility: insoluble in water, soluble in organic solvents such as dichloromethane, ethyl acetate
Use:
FMOC-DL-Phenylalanine is commonly used in solid-phase synthesis, peptide chemistry, and protein research. It is a commonly used amino acid protecting agent that can protect the amine group without affecting the reaction of other functional groups. When the peptide chain is synthesized, it can be used as a protective agent for the amino acid unit, protecting the amine group, and removing it when necessary, so that it can participate in the extension reaction of the peptide chain. It can also be used as an important intermediate in pharmaceutical research and synthetic chemistry.
Preparation Method:
A common preparation method is to react DL-phenylalanine with FMOC-OSu (9-fluorothiocarbyl chloride) under base catalysis to generate FMOC-DL-phenylalanine.
Safety Information:
FMOC-DL-phenylalanine has no obvious danger under correct operation. However, it is a chemical, and the following safety precautions should be paid attention:
-Avoid direct contact with skin and eyes, and avoid inhaling dust or gas.
-Wear appropriate safety gloves, goggles and overalls during operation.
-If contact or ingestion occurs, immediately rinse the affected area with plenty of water and seek medical help.
-Follow proper laboratory practices and safe operating procedures during storage and handling.
Last Update：2024-04-09 20:45:29
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