1015460-59-9
7-BROMO-5H-PYRIDO[4,3-B]INDOLE
CAS: 1015460-59-9
Molecular Formula: C11H7BrN2
1015460-59-9 - Names and Identifiers
| Name | 7-BROMO-5H-PYRIDO[4,3-B]INDOLE |
| Synonyms | 7-BROMO-5H-PYRIDO[4,3-B]INDOLE 5H-Pyrido[4,3-b]indole, 7-bromo- |
| CAS | 1015460-59-9 |
1015460-59-9 - Physico-chemical Properties
| Molecular Formula | C11H7BrN2 |
| Molar Mass | 247.09 |
| Density | 1.699±0.06 g/cm3(Predicted) |
| Boling Point | 443.6±25.0 °C(Predicted) |
| pKa | 14.04±0.40(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
1015460-59-9 - Reference Information
| Application | 7-bromo-5H-pyridino [4,3-B] indole is a pharmaceutical intermediate, which can be composed of 3-bromo-4-Nitropyridine and 4-bromophenylboronic acid react through Suzuki to obtain 3-(4-bromobenzene)-4-nitropyridine, then the ring is closed to obtain 7-bromo-5H-pyrido [4,3-B] indole. |
| Uses | 7-bromo-5H-pyridino [4,3-B] indole is a heterocyclic organic substance, mainly used as a pharmaceutical intermediate. |
| preparation | step 1. preparation of 3-(4-bromobenzene)-4-nitropyridine 2.02g(10.0mmol) 3-bromo-4-nitropyridine, 2.20g(11.0mmol) 4-bromophenylboronic acid, 0.46g(0.4mmol) tetraphenylphosphine palladium, 1.33g(25mmol)NaCO3 is dissolved in 60mL of dioxane and 10mL of water, refluxed at 110 ℃ for 12h, cooled, poured into 80mL of water, then extracted with 100mL of ethyl acetate for three times, and dried with anhydrous magnesium sulfate. The solvent was removed in vacuum, and the solid was separated by column chromatography to obtain 2.1g of yellow solid product (yield: 75%). The preparation of 7-bromo-5H-pyridino [4,3-B] indole was 2..1.68g 3-(4-bromobenzene)-4-nitropyridine was dissolved in 60mL triethyl phosphite, heated at 110 ℃ for 3h under nitrogen protection, cooled, and the obtained solid was separated by column chromatography, 1.05g of brown-yellow solid product (yield: 71%) was obtained. |
Last Update：2024-04-09 21:04:16
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View History
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