1018678-39-1
4-Chloro-2-(trifluoromethyl)nicotinic acid
CAS: 1018678-39-1
Molecular Formula: C7H3ClF3NO2
1018678-39-1 - Names and Identifiers
| Name | 4-Chloro-2-(trifluoromethyl)nicotinic acid |
| Synonyms | 4-Chloro-2-trifluoromethylnicotinic acid 4-Chloro-2-(trifluoromethyl)nicotinic acid 4-Chloro-2-(trifluoroMethyl)nicotinic acid 4-Chloro-2-(trifluoromethyl)pyridin-3-carboxylic acid |
| CAS | 1018678-39-1 |
| InChI | InChI=1S/C7H3ClF3NO2/c8-3-1-2-12-5(7(9,10)11)4(3)6(13)14/h1-2H,(H,13,14) |
1018678-39-1 - Physico-chemical Properties
| Molecular Formula | C7H3ClF3NO2 |
| Molar Mass | 225.55 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
1018678-39-1 - Introduction
4-Chloro-2-trifluoromethylnicotinic acid is an organic compound with the chemical formula C5H2ClF3NO2 and a molecular weight of 183.52g/mol. The following is a description of the properties, uses, preparation and safety information of 4-chloro-2-trifluoromethylnicotinic acid:
Nature:
-Appearance: 4-chloro-2-trifluoromethylnicotinic acid is a white to yellow crystalline powder, odorless.
-Solubility: It is insoluble in water, but can be dissolved in a variety of organic solvents, such as ethanol, dimethylformamide, etc.
Use:
-Pharmaceutical field: 4-chloro-2-trifluoromethyl nicotinic acid is an important intermediate compound, which can be used to prepare aminophylline, neostigmine and other drugs.
-Agricultural field: It is also used as a raw material for pesticides and herbicides, and is used in agriculture to control pests.
Preparation Method:
4-Chloro -2-trifluoromethyl nicotinic acid has two main preparation methods:
-Chlorination method: 4-chloro-2-trifluoromethylnicotinic acid is obtained by reacting 2-amino-4-trifluoromethylquinoline with cuprous chloride.
-bromination method: 4-chloro-2-trifluoromethylnicotinic acid is obtained by reacting 3-bromo-4-trifluoromethylthiophene with 2-aminoacetic acid bromide, followed by hydrogenation and deprotection reactions, and then by chlorination treatment.
Safety Information:
-4-Chloro-2-trifluoromethylnicotinic acid dust can cause eye and respiratory tract irritation, and direct contact should be avoided.
-Wear appropriate protective equipment such as masks, goggles and gloves when handling it.
-Avoid inhaling its dust or solution, and use it in a well-ventilated place if necessary.
-In case of accidental contact or misuse, seek medical attention and bring the product packaging or label.
Nature:
-Appearance: 4-chloro-2-trifluoromethylnicotinic acid is a white to yellow crystalline powder, odorless.
-Solubility: It is insoluble in water, but can be dissolved in a variety of organic solvents, such as ethanol, dimethylformamide, etc.
Use:
-Pharmaceutical field: 4-chloro-2-trifluoromethyl nicotinic acid is an important intermediate compound, which can be used to prepare aminophylline, neostigmine and other drugs.
-Agricultural field: It is also used as a raw material for pesticides and herbicides, and is used in agriculture to control pests.
Preparation Method:
4-Chloro -2-trifluoromethyl nicotinic acid has two main preparation methods:
-Chlorination method: 4-chloro-2-trifluoromethylnicotinic acid is obtained by reacting 2-amino-4-trifluoromethylquinoline with cuprous chloride.
-bromination method: 4-chloro-2-trifluoromethylnicotinic acid is obtained by reacting 3-bromo-4-trifluoromethylthiophene with 2-aminoacetic acid bromide, followed by hydrogenation and deprotection reactions, and then by chlorination treatment.
Safety Information:
-4-Chloro-2-trifluoromethylnicotinic acid dust can cause eye and respiratory tract irritation, and direct contact should be avoided.
-Wear appropriate protective equipment such as masks, goggles and gloves when handling it.
-Avoid inhaling its dust or solution, and use it in a well-ventilated place if necessary.
-In case of accidental contact or misuse, seek medical attention and bring the product packaging or label.
Last Update：2024-04-09 02:00:40
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