1020415-08-0
Cbz-(4-(Aminomethyl)phenyl)methanol
CAS: 1020415-08-0
Molecular Formula: C16H17NO3
1020415-08-0 - Names and Identifiers
1020415-08-0 - Physico-chemical Properties
| Molecular Formula | C16H17NO3 |
| Molar Mass | 271.31 |
1020415-08-0 - Introduction
Cbz-4-aminomethylbenzyl alcohol (Carbobenzyloxy-4-aminomethylbenzyl alcohol) is an important intermediate in organic synthesis and is commonly used in pharmaceutical synthesis.
Nature:
-Appearance: White crystalline solid
-Solubility: Soluble in organic solvents such as ether and dimethylformamide, insoluble in water
-Molecular formula: C16H17NO2
-Molecular weight: 255.31g/mol
Use:
- Cbz-4-aminomethyl benzyl alcohol is a commonly used protecting group, which can be used to protect the activity of amino and amino alcohol groups, so as to avoid non-specific amino reactions during the reaction. It is widely used in the synthesis of drugs, especially in the synthesis of peptides and amino-containing compounds.
-As a protecting group, it can be removed by a simple deprotection reaction after the amino reaction is completed.
Preparation Method:
Cbz-4-amine methyl benzyl alcohol is generally synthesized by the following steps:
1. Benzyl alcohol and cyclohexyl maleic anhydride are reacted under acid catalysis to form 4-hydroxybenzoic acid (p-Hydroxybenzoic acid).
2. 4-hydroxybenzoic acid reacts with sodium hypochlorite to generate 4-chlorobenzoic acid (p-Chlorobenzoic acid).
3. 4-Chlorobenzoic acid and aminomethyl benzyl alcohol (4-Aminomethylbenzyl alcohol) were transesterified in the presence of potassium carbonate to obtain Cbz-4-aminomethyl benzyl alcohol.
Safety Information:
Cbz-4-amine methyl benzyl alcohol is generally safe under normal use conditions, but it still needs to be handled with caution. Chemical protective gloves and safety glasses should be worn when exposed to the compound to prevent skin and eye contact. If inhaled or ingested, seek medical attention as soon as possible. Avoid contact with ignition and heat sources. Store should be sealed and kept in a dry, cool place, away from fire and oxidant.
Nature:
-Appearance: White crystalline solid
-Solubility: Soluble in organic solvents such as ether and dimethylformamide, insoluble in water
-Molecular formula: C16H17NO2
-Molecular weight: 255.31g/mol
Use:
- Cbz-4-aminomethyl benzyl alcohol is a commonly used protecting group, which can be used to protect the activity of amino and amino alcohol groups, so as to avoid non-specific amino reactions during the reaction. It is widely used in the synthesis of drugs, especially in the synthesis of peptides and amino-containing compounds.
-As a protecting group, it can be removed by a simple deprotection reaction after the amino reaction is completed.
Preparation Method:
Cbz-4-amine methyl benzyl alcohol is generally synthesized by the following steps:
1. Benzyl alcohol and cyclohexyl maleic anhydride are reacted under acid catalysis to form 4-hydroxybenzoic acid (p-Hydroxybenzoic acid).
2. 4-hydroxybenzoic acid reacts with sodium hypochlorite to generate 4-chlorobenzoic acid (p-Chlorobenzoic acid).
3. 4-Chlorobenzoic acid and aminomethyl benzyl alcohol (4-Aminomethylbenzyl alcohol) were transesterified in the presence of potassium carbonate to obtain Cbz-4-aminomethyl benzyl alcohol.
Safety Information:
Cbz-4-amine methyl benzyl alcohol is generally safe under normal use conditions, but it still needs to be handled with caution. Chemical protective gloves and safety glasses should be worn when exposed to the compound to prevent skin and eye contact. If inhaled or ingested, seek medical attention as soon as possible. Avoid contact with ignition and heat sources. Store should be sealed and kept in a dry, cool place, away from fire and oxidant.
Last Update：2024-04-09 02:00:40
