1026680-07-8

Name	LB-100
Synonyms	LB-100 CS-1762 LB-100, 1026680-07-8 3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID 3-(1-methylpiperazine-4-carbonyl)-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid methyl 2,5-dimethyl-1-[(2-methylpropan-2-yl)oxycarbonylamino]pyrrole-3-carboxylate LB-100 LB-100 3-(4-METHYLPIPERAZINE-1-CARBONYL)-7-OXABICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID
CAS	1026680-07-8

Molecular Formula	C13H20N2O4
Molar Mass	268.3089
Melting Point	>214°C (dec.)
Solubility	DMSO (Very Slightly, Heated), Methanol (Very Slightly, Heated)
Appearance	Solid
Color	White
Storage Condition	Amber Vial, -20°C Freezer, Under inert atmosphere
In vitro study	LB-100 can effectively inhibit the growth of BxPc-3 and Panc-1 cells, IC50 values were 2.3 μm and 1.7 μm. After BxPc-3, Panc-1 and SW1990 cells were treated with LB-100, the activity of PP2A decreased by 30-50%. LB-100 increased the intracellular doxorubicin concentration (about 2.5 times that of the control group) and made the tumor cells more sensitive to doxorubicin cytotoxicity. LB-100 increases VEGF secretion, thereby enhancing hif-1α-VEGF mediated angiogenesis.
In vivo study	In a mouse pancreatic cancer xenograft model, LB-100 (2 mg/kg, I. P.) improved the efficacy of the chemotherapeutic drug doxorubicin. LB-100 increased tumor microvessel density and tumor surface blood flow velocity.

Last Update：2024-01-02 23:10:35

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