| Molecular Formula | C20H15ClF3N5 |
| Molar Mass | 417.8148 |
| Density | 1.458±0.06 g/cm3(Predicted) |
| Solubility | DMSO: ≥ 30 mg/mL |
| Appearance | Form solid, color White |
| pKa | 12.81±0.40(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| Physical and Chemical Properties | Bioactive Pexidartinib (PLX3397) is an orally effective multi-target CSF-1R,Kit (c-Kit), and FLT3 receptor tyrosine kinase inhibitor with IC50 of 20 nM, 10 nM, and 160 nM, respectively. Pexidartinib (PLX3397) can induce apoptosis and necrosis and has antitumor activity. Phase 3. |
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.393 ml | 11.967 ml | 23.934 ml |
| 5 mM | 0.479 ml | 2.393 ml | 4.787 ml |
| 10 mM | 0.239 ml | 1.197 ml | 2.393 ml |
| 5 mM | 0.048 ml | 0.239 ml | 0.479 ml |