1034301-08-0
3',5'-di-o-p-chlorobenzoyl-2-deoxy-5-azacytosine
CAS: 1034301-08-0
Molecular Formula: C22H18Cl2N4O6
1034301-08-0 - Names and Identifiers
1034301-08-0 - Physico-chemical Properties
| Molecular Formula | C22H18Cl2N4O6 |
| Molar Mass | 505.31 |
| Density | 1.58 |
| Melting Point | >182°C (dec.) |
| Boling Point | 642.6±65.0 °C(Predicted) |
| Solubility | Chloroform (Very Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated) |
| Appearance | Solid |
| Color | White |
| pKa | 3.38±0.20(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
1034301-08-0 - Introduction
3 ',5'-di-p-chlorobenzoyloxy-2-deoxy-5-azacytidine, also known as ddACT, is a nucleoside compound.
Properties: ddACT is a white crystalline solid, chemically a dimer, composed of two molecules. It is highly soluble in water, but often precipitates in organic solvents. It belongs to the amide compound, has a strong intramolecular hydrogen bonding force, has a strong affinity for water molecules.
Uses: ddACT is mainly used for nucleic acid sequence analysis and drug development. It is a special nucleoside analog, mainly used in DNA sequencing technology, can be used as a substrate for chain termination reaction, used to label the end of DNA. In addition, ddACT can also be used to synthesize drugs with antiviral activity.
Production Method: ddACT can be obtained by chemical synthesis. A common synthesis method is to react 2-deoxycytidine with 3 ',5'-di-p-chlorobenzaldehyde to obtain 3 ',5'-di-chlorobenzoyloxy-2-deoxycytidine, and then Under alkaline conditions, the 3 ',5'-di-chlorobenzoyloxy-2-deoxycytidine is reacted with arylamine to further transform it into 3 ',5'-Di-p-chlorobenzoyloxy-2-deoxy-5-azacytidine.
Safety information: Due to the strong chemical properties of ddACT, it should follow safe operating procedures during operation. It may be irritating to the human skin, eyes and respiratory tract, so wear appropriate protective equipment when working to avoid direct contact. During storage and handling, it should be properly preserved and avoid contact with oxidants and other substances.
Properties: ddACT is a white crystalline solid, chemically a dimer, composed of two molecules. It is highly soluble in water, but often precipitates in organic solvents. It belongs to the amide compound, has a strong intramolecular hydrogen bonding force, has a strong affinity for water molecules.
Uses: ddACT is mainly used for nucleic acid sequence analysis and drug development. It is a special nucleoside analog, mainly used in DNA sequencing technology, can be used as a substrate for chain termination reaction, used to label the end of DNA. In addition, ddACT can also be used to synthesize drugs with antiviral activity.
Production Method: ddACT can be obtained by chemical synthesis. A common synthesis method is to react 2-deoxycytidine with 3 ',5'-di-p-chlorobenzaldehyde to obtain 3 ',5'-di-chlorobenzoyloxy-2-deoxycytidine, and then Under alkaline conditions, the 3 ',5'-di-chlorobenzoyloxy-2-deoxycytidine is reacted with arylamine to further transform it into 3 ',5'-Di-p-chlorobenzoyloxy-2-deoxy-5-azacytidine.
Safety information: Due to the strong chemical properties of ddACT, it should follow safe operating procedures during operation. It may be irritating to the human skin, eyes and respiratory tract, so wear appropriate protective equipment when working to avoid direct contact. During storage and handling, it should be properly preserved and avoid contact with oxidants and other substances.
Last Update：2024-04-09 21:04:16
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View History
1034301-08-0
59288-43-6
105-67-9
64426-35-3
403860-24-2
Yellow 3RS
6272-45-3
Dioctadecyl Dimethyl Ammonium Chloride
se-1520
TRICHLOROTRIETHYLAMINEHYDROCHLORIDE
59288-43-6
105-67-9
64426-35-3
403860-24-2
Yellow 3RS
6272-45-3
Dioctadecyl Dimethyl Ammonium Chloride
se-1520
TRICHLOROTRIETHYLAMINEHYDROCHLORIDE