1053656-65-7
2-Methyl-2-propanyl 6-fluoro-2-pyridinecarboxylate
CAS: 1053656-65-7
Molecular Formula: C10H12FNO2
1053656-65-7 - Names and Identifiers
1053656-65-7 - Physico-chemical Properties
| Molecular Formula | C10H12FNO2 |
| Molar Mass | 197.21 |
| Density | 1.131±0.06 g/cm3(Predicted) |
| Boling Point | 277.6±25.0 °C(Predicted) |
| pKa | -1.08±0.10(Predicted) |
| Storage Condition | Room Temprature |
| Sensitive | IRRITANT |
| MDL | MFCD10568316 |
1053656-65-7 - Introduction
Tert-butyl 6-fluoro-2-pyridinecarboxylate is an organic compound with the chemical formula C9H11FO2. The following is a description of its nature, use, preparation and safety information:
Nature:
6-fluoro-2-pyridinecarboxylic acid tert-butyl ester is a colorless or slightly yellow liquid with a special fragrance. It has a low boiling point and melting point and is soluble in common organic solvents such as ethanol and dimethylformamide.
Use:
6-fluoro-2-pyridinecarboxylic acid tert-butyl ester is mainly used as an intermediate in drug synthesis. It can be used as a raw material for the synthesis of drugs, widely used in the synthesis of various antiviral, antibacterial, anti-tumor and anti-inflammatory drugs.
Preparation Method:
The preparation method of 6-fluoro-2-pyridine carboxylic acid tert-butyl ester can be obtained by reacting 2-picolinic acid with tert-butanol, and then fluorinating the product. The reaction conditions generally require the use of a fluorinating agent, such as hydrogen fluoride or boron trifluoride, to facilitate the reaction.
Safety Information:
When using or handling 6-fluoro-2-pyridinecarboxylic acid tert-butyl ester, the following safety precautions should be paid attention:
1. Avoid contact with skin and eyes, and avoid inhaling its vapor or dust.
2. The operation should be equipped with appropriate protective equipment, including chemical goggles, chemical gloves and protective clothing.
3. storage should be away from fire and oxidant, sealed and stored in a dry, cool place, and isolated from other chemicals.
4. When leaking or splashing into the skin, rinse immediately with plenty of water and seek medical help.
5. It is strictly prohibited to discharge into water bodies or drainage systems.
When using 6-fluoro-2-pyridinecarboxylic acid tert-butyl ester, strict safety procedures should be followed, and the substance should be properly managed and stored.
Nature:
6-fluoro-2-pyridinecarboxylic acid tert-butyl ester is a colorless or slightly yellow liquid with a special fragrance. It has a low boiling point and melting point and is soluble in common organic solvents such as ethanol and dimethylformamide.
Use:
6-fluoro-2-pyridinecarboxylic acid tert-butyl ester is mainly used as an intermediate in drug synthesis. It can be used as a raw material for the synthesis of drugs, widely used in the synthesis of various antiviral, antibacterial, anti-tumor and anti-inflammatory drugs.
Preparation Method:
The preparation method of 6-fluoro-2-pyridine carboxylic acid tert-butyl ester can be obtained by reacting 2-picolinic acid with tert-butanol, and then fluorinating the product. The reaction conditions generally require the use of a fluorinating agent, such as hydrogen fluoride or boron trifluoride, to facilitate the reaction.
Safety Information:
When using or handling 6-fluoro-2-pyridinecarboxylic acid tert-butyl ester, the following safety precautions should be paid attention:
1. Avoid contact with skin and eyes, and avoid inhaling its vapor or dust.
2. The operation should be equipped with appropriate protective equipment, including chemical goggles, chemical gloves and protective clothing.
3. storage should be away from fire and oxidant, sealed and stored in a dry, cool place, and isolated from other chemicals.
4. When leaking or splashing into the skin, rinse immediately with plenty of water and seek medical help.
5. It is strictly prohibited to discharge into water bodies or drainage systems.
When using 6-fluoro-2-pyridinecarboxylic acid tert-butyl ester, strict safety procedures should be followed, and the substance should be properly managed and stored.
Last Update：2024-04-09 15:17:50
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