105956-97-6
Clinafloxacin
CAS: 105956-97-6
Molecular Formula: C17H17ClFN3O3
105956-97-6 - Names and Identifiers
105956-97-6 - Physico-chemical Properties
| Molecular Formula | C17H17ClFN3O3 |
| Molar Mass | 365.79 |
| Density | 1.573±0.06 g/cm3(Predicted) |
| Melting Point | 253-258 C |
| Boling Point | 592.3±50.0 °C(Predicted) |
| Flash Point | 312°C |
| Solubility | Acetic Acid (Slightly), DMSO (Slightly) |
| Vapor Presure | 7.14E-15mmHg at 25°C |
| Appearance | Solid |
| Color | Pale Beige |
| pKa | 6.39±0.50(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Refractive Index | 1.684 |
| In vitro study | Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid class that is currently used for intravenous and oral treatment of serious infections. Clinafloxacin is a new type of fluoroquinolone. It has broad spectrum activity against Gram-positive, Gram-negative, and anaerobic pathogens in vitro. Clinafloxacin had high activity against Streptococcus pneumoniae 7785 (MIC,0.125 μg/ml), and non-gyrA or parC quinolone-resistant mutations alone had a better effect on this activity. Compared to ofloxacin,levofloxacin,sparfloxacin,grepafloxacin, and trovafloxacin, Clinafloxacin is considered the most effective fluoroquinolone against S. pneumoniae and is currently considered an antistreptococcus pneumoniae drug. |
| In vivo study | Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model. With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis. |
105956-97-6 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R63 - Possible risk of harm to the unborn child |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37 - Wear suitable protective clothing and gloves. |
| RTECS | VB1800600 |
105956-97-6 - Reference
| Reference Show more | 1. [IF=6.057] Song Hu et al."Reliable performance of aggregation-induced emission nanoparticle-based lateral flow assay for norfloxacin detection in nine types of animal-derived food."Talanta. 2020 Nov;219:121245 |
105956-97-6 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.734 ml | 13.669 ml | 27.338 ml |
| 5 mM | 0.547 ml | 2.734 ml | 5.468 ml |
| 10 mM | 0.273 ml | 1.367 ml | 2.734 ml |
| 5 mM | 0.055 ml | 0.273 ml | 0.547 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Featured ProductsSpot supply
Product Name: Clinafloxacin Visit Supplier Webpage Request for quotationCAS: 105956-97-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Clinafloxacin Request for quotationCAS: 105956-97-6
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Clinafloxacin Visit Supplier Webpage Request for quotationCAS: 105956-97-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: AM-1091; CI-960; PD 127391 Visit Supplier Webpage Request for quotationCAS: 105956-97-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Clinafloxacin Visit Supplier Webpage Request for quotationCAS: 105956-97-6
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Clinafloxacin Visit Supplier Webpage Request for quotationCAS: 105956-97-6
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: Clinafloxacin Visit Supplier Webpage Request for quotationCAS: 105956-97-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Clinafloxacin Visit Supplier Webpage Request for quotationCAS: 105956-97-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Clinafloxacin Request for quotationCAS: 105956-97-6
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Clinafloxacin Visit Supplier Webpage Request for quotationCAS: 105956-97-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: AM-1091; CI-960; PD 127391 Visit Supplier Webpage Request for quotationCAS: 105956-97-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Clinafloxacin Visit Supplier Webpage Request for quotationCAS: 105956-97-6
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Clinafloxacin Visit Supplier Webpage Request for quotationCAS: 105956-97-6
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: Clinafloxacin Visit Supplier Webpage Request for quotationCAS: 105956-97-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History