1063-77-0
Nomilin
CAS: 1063-77-0
Molecular Formula: C28H34O9
1063-77-0 - Names and Identifiers
1063-77-0 - Physico-chemical Properties
| Molecular Formula | C28H34O9 |
| Molar Mass | 514.56 |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Melting Point | 278-279° |
| Boling Point | 657.7±55.0 °C(Predicted) |
| Specific Rotation(α) | D23 -95.7° |
| Flash Point | 351.6°C |
| Solubility | It is difficult to dissolve in water, and has greater solubility in methanol and ethanol. |
| Vapor Presure | 3.57E-17mmHg at 25°C |
| Appearance | White crystalline powder |
| Color | White to Off-White |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.574 |
| MDL | MFCD00075979 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Fructus Aurantii, seeds of Rutaceae plants, pericarp, etc. |
| In vitro study | Nomilin treatment significantly mitigated cell death and decreased lactate dehydrogenase (LDH) release and ROS production in SH-SY5Y cells induced by oxygen-glucose deprivation (OGD), which was almost abolished by Nrf2 knockdown. |
| In vivo study | Nomilin attenuated blood-brain barrier (BBB) disruption in MCAO rats, which might be associated with alleviating the loss of tight junction proteins, including ZO-1 and occludin-5. |
1063-77-0 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29322090 |
1063-77-0 - Reference
| Reference Show more | 1. Li Yibing, Gong Guizhi, Peng Zhuchun, Wang Yanjie, Wang Jiong, Hong Qibin. Changes of Limonin Content in Juice of Different Sweet Orange Varieties [J]. Food and fermentation industry 2017 43(02):201-205. 2. [IF = 3.463] Yun Liu et al."Structural diversity and distribution of limonoids in pummelo (Citrus grandis) fruit revealed by comprehensive UHPLC-MS/MS analysis." Sci Hortic-Amsterdam. 2021 May;282:109996 3. [IF = 3] Qu Lala et al."Phenotypic assessment and screening of ETA/ETB receptors with label-free dynamic mass redistribution say." N-S Arch Pharmacol. 2020 Jun;393(6):937-950 4. [IF = 2.408] Wei Ling et al."Evaluation of Pomelo Seed Extracts as Natural Antioxidant, Antibacterial, Herbicidal Agents, and Their Functional Components." Chemistry & Biodiversity. 2021 Oct 27 |
1063-77-0 - Reference Information
| physical and chemical properties | nomilin (Nomilin) is the main limonin compound in citrus, which is a triterpenoid The secondary metabolite of plants is mainly found in Rutaceae and Meliaceae plants, especially in the seeds of Citrus. |
| biological activity | Nomilin are limonin compounds obtained from citrus extracts. Nomilin is an anti-obesity and hypoglycemic drug. |
| in vitro study | Nomilin treatment significantly mitigated cell death and decreased lactate dehydrogenase (LDH) release and ROS production in SH-SY5Y cells induced by oxygen-glucose deprivation (OGD), which was almost abolished by Nrf2 knockdown. |
| in vivo research | Nomilin attenuated blood-brain barrier (BBB) disruption in MCAO rats, which might be associated with alleviating the loss of junction proteins, including ZO-1 and occludin-5. |
| chemical properties | white crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from seeds and peels of rutaceae plants made in bitter orange. |
| use | nomelin has anti-cancer, insecticidal and anti-feeding, analgesic and anti-inflammatory, hypnotic and anti-anxiety effects. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: Limonin analogs can significantly inhibit the growth of human breast cancer cell MCF-7 in vitro, and there is a dose-effect relationship. |
Last Update：2024-04-09 21:21:28
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