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106861-44-3

Mivacurium chloride

CAS: 106861-44-3

Molecular Formula: C58H80Cl2N2O14

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106861-44-3 - Names and Identifiers

Name Mivacurium chloride
Synonyms rac-Mivacron
rac-BW-B 1090
rac-BW-B 1090U
Mivacurium chloride
MIVACURIUM CHLORIDE
BW B1090U Dichloride
rac Mivacurium Chloride
2,2'-{[(4E)-1,8-dioxooct-4-ene-1,8-diyl]bis(oxypropane-3,1-diyl)}bis[6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium] dichloride
(1R,1'R)-2,2'-{[(4E)-1,8-Dioxooct-4-en-1,8-diyl]bis(oxypropan-3,1-diyl)}bis[6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisochinolinium]dichlorid
[R-[R*,R*-(E)]]2,2'-(1,8-Dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl)bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxyphenyl)isoquinolinium] dichloride
(1R,1'R)-2,2'-{[(4E)-1,8-Dioxooct-4-ene-1,8-diyl]bis(oxypropane-3,1-diyl)}bis[6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium] dichloride
dichlorure de (1R,1'R)-2,2'-{[(4E)-1,8-dioxooct-4-ène-1,8-diyl]bis(oxypropane-3,1-diyl)}bis[6,7-diméthoxy-2-méthyl-1-(3,4,5-triméthoxybenzyl)-1,2,3,4-tétrahydroisoquinoléinium]
[R-[R*,R*-(E)]]-2,2'-(1,8-Dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl)bis(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinolinium) Dichloride
rel-(1R,1'R)-2,2'-[[(4E)-1,8-Dioxo-4-octene-1,8-diyl]bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]- isoquinolinium Chloride
isoquinolinium, 2,2'-[[(4E)-1,8-dioxo-4-octene-1,8-diyl]bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-, dichloride, (1R,1'R)-
CAS 106861-44-3
EINECS 643-006-4
InChI InChI=1/C58H80N2O14.2ClH/c1-59(25-21-41-35-47(63-3)49(65-5)37-43(41)45(59)29-39-31-51(67-7)57(71-11)52(32-39)68-8)23-17-27-73-55(61)19-15-13-14-16-20-56(62)74-28-18-24-60(2)26-22-42-36-48(64-4)50(66-6)38-44(42)46(60)30-40-33-53(69-9)58(72-12)54(34-40)70-10;;/h13-14,31-38,45-46H,15-30H2,1-12H3;2*1H/q+2;;/p-2/b14-13+;

106861-44-3 - Physico-chemical Properties

Molecular FormulaC58H80Cl2N2O14
Molar Mass1100.17
Specific Rotation(α)20D -62.7° (c = 1.9 in water)
Storage ConditionHygroscopic, -20°C Freezer, Under Inert Atmosphere
Physical and Chemical PropertiesAmorphous solid. [Α] D20-62.7 °(C = 1.9, water).
In vitro study Mivacurium induces LAD2 cell degranulation in a dose-dependent manner. Mivacurium stimulates intracellular Ca 2+ influx in MRGPRX2-HEK293 cells but not in NC-HEK293 cells. Mivacurium induces the release of only low levels of mediators in LAD2 cells transfected with MRGPRX2-targeted small interfering siRNA.
In vivo study Mivacurium causes pseudo-allergic reactions in C57 wild-type mice by inducing mast cells to release histamine and a decrease in body temperature. Mivacurium is rapidly hydrolyzed in the plasma and has a short duration of action (< 10 min). Mivacurium has many advantages, such as a rapid effect, nonneurological toxicity and a lack of heart rate alteration.

106861-44-3 - Reference Information

Biological activity Mivacurium dichloride is a benzyl isoquinoline derivative, and is also a short-acting non-depolarizing neuromuscular blocker and skeletal muscle relaxant. Mivacurium dichloride can be coupled to nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal discs of muscle cells.
use short-acting non-polarized neuromuscular blocker, short-acting muscle relaxant. It can be used for short-term surgical procedures, and can be used as an auxiliary drug for relaxing skeletal muscle, promoting tracheal intubation and general anesthesia during mechanical ventilation.
Production method 5 ', 8-dimethoxy-N-methylpapaverine and 3-chloropropanol, in the presence of sodium iodide, reflux in 2-butanone. The obtained quaternary ammonium salt and octyl -4-alkylene diacyl chloride were reacted in dichloroethane at room temperature to obtain mikuronium chloride.
Last Update：2024-04-09 21:21:28
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