1072-85-1
2-Bromofluorobenzene
CAS: 1072-85-1
Molecular Formula: C6H4BrF
1072-85-1 - Names and Identifiers
| Name | 2-Bromofluorobenzene |
| Synonyms | o-fluorobromobenzene 2-BROMOFLUOROBENZENE 2-Bromofluorobenzene 2-Fluorobromobenzene 1-Bromo-2-fluorobenzene O-BROMO-2-FLUOROBENZENE 2-BROMO-1-FLUORO-BENZENE Benzene, 1-bromo-2-fluoro- BromofluorobenzeneBromofluorobenzene |
| CAS | 1072-85-1 |
| EINECS | 214-018-3 |
| InChI | InChI=1/C6H4BrF/c7-5-3-1-2-4-6(5)8/h1-4H |
| InChIKey | IPWBFGUBXWMIPR-UHFFFAOYSA-N |
1072-85-1 - Physico-chemical Properties
| Molecular Formula | C6H4BrF |
| Molar Mass | 175 |
| Density | 1.601g/mLat 25°C(lit.) |
| Melting Point | -8°C |
| Boling Point | 78-82°C50mm Hg |
| Flash Point | 110°F |
| Water Solubility | insoluble |
| Solubility | 0.35g/l |
| Vapor Presure | 4.67mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.601 |
| Color | Clear colorless to light yellow |
| BRN | 1071819 |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.534(lit.) |
| Physical and Chemical Properties | Light yellow liquid. Boiling point 155 ℃-157 ℃, flash point 43 ℃, refractive index 1.5340, specific gravity 1.601. |
| Use | Used as pharmaceutical, pesticide intermediates |
1072-85-1 - Risk and Safety
| Risk Codes | R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S16 - Keep away from sources of ignition. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| RTECS | DA1050000 |
| TSCA | T |
| HS Code | 29036990 |
| Hazard Note | Flammable/Irritant |
| Hazard Class | 3 |
| Packing Group | III |
1072-85-1 - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | O-fluorobromo-benzene is mainly used as a pharmaceutical, pesticide intermediates, is a variety of chemical raw materials harmful, eye irritation, respiratory system and skin chemicals, the existing production of O-fluorobromo generally adopt external protection, for the emission of waste gas has not taken effective measures. |
| preparation method | The reaction bottle is sequentially stirred with O-fluoroaniline and hydrobromic acid, and a large amount of purplish solid is exothermic and precipitated, with a maximum temperature of 60 ℃, after stirring for 5 minutes, sodium nitrite solution is added dropwise in the ice salt bath below -10 ℃, and the process of dropwise addition is exothermic. The liquid solution gradually turns to Orange and is clarified, and is dropped for about 40 minutes, cold, put cuprous bromide, hydrobromic acid, water into the reaction bottle with distillation device, heat up to 120~130 ℃ in the oil bath, and pass through the water vapor. When the internal temperature is about 105 ℃, the water vapor is distilled out, the diazonium salt is started to be added dropwise, and a large number of bubbles are generated at this time. The dropping acceleration is controlled to maintain the distillation state, so as to ensure that the generated O-fluorobromobenzene is rapidly taken out by water vapor. After about 50 minutes of dropping, distillation was stopped for another 5 minutes. The oil layer was separated and washed with saturated brine. After filtration, the water content of the oil layer was measured to be 0.04% to obtain O-fluorobromo. |
| Use | Pharmaceutical, pesticide, liquid crystal material intermediates. used as pharmaceutical and pesticide intermediates |
Last Update：2024-04-09 21:11:58
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