1073353-50-0

1073353-50-0 - Names and Identifiers

Name	5-Bromo-2-fluoropyridine-3-boronic acid, pinacol ester
Synonyms	5-Bromo-2-fluoro-pyridine-3-boronic acid picol ester 5-BROMO-2-FLUOROPYRIDINE-3-BORONIC ACID PINACOL ESTER 5-Bromo-2-fluoropyridine-3-boronic acid, pinacol ester 5-Bromo-2-fluoropyridin-3-ylboronic acid pinacol ester 5-Bromo-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) 5-Bromo-2-fluoro-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2-(5-Bromo-2-fluoro-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 5-BROMO-2-FLUORO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]-DIOXABOROLAN-2-YL)PYRIDINE Pyridine, 5-bromo-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CAS	1073353-50-0
InChI	InChI=1/C11H14BBrFNO2/c1-10(2)11(3,4)17-12(16-10)8-5-7(13)6-15-9(8)14/h5-6H,1-4H3

1073353-50-0 - Physico-chemical Properties

Molecular Formula	C11H14BBrFNO2
Molar Mass	301.95
Density	1.39±0.1 g/cm3(Predicted)
Melting Point	46-49°C
Boling Point	346.2±42.0 °C(Predicted)
Flash Point	110℃
pKa	-2.80±0.22(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
MDL	MFCD08689619

1073353-50-0 - Risk and Safety

WGK Germany

1073353-50-0 - Introduction

5-Bromo-2-fluoropyridine-3-boronic acid pinacol ester is an organic compound with the chemical formula C9H6BF2BrNO2. It is a white solid with good solubility.

This compound is mainly used as a corresponding reagent in the pharmaceutical and medical fields. It is often used in boronation reagents in organic synthesis reactions, such as Suzuki-Miyaura coupling reactions, and it can effectively catalyze the coupling reaction between aryl and aryl. This compound is also widely used in pharmaceutical synthesis, materials science and organic electronics.

the method for preparing 5-bromo-2-fluoropyridine-3-boronic acid pinacol ester is relatively simple, usually through the reaction between 2,3-difluorophenylhydrazone and bromopyridine, and through nucleophilic substitution reaction under alkali catalysis.

This compound requires attention to safety when used. It may cause irritation to the skin, eyes and respiratory tract, so wear appropriate personal protective equipment such as gloves, goggles and protective masks during operation. At the same time, it should be operated in a well-ventilated place to avoid inhaling its vapor. During storage, it should be kept in a dry, cool place, and away from fire and oxidizing agents.

Last Update：2024-04-09 21:11:58