107842-74-0
4-Amino-3-bromo-2-hydroxypyridine
CAS: 107842-74-0
Molecular Formula: C5H5BrN2O
107842-74-0 - Names and Identifiers
| Name | 4-Amino-3-bromo-2-hydroxypyridine |
| Synonyms | 4-Amino-3-bromopyridin-2-ol 4-amino-3-bromopyridin-2(1H)-one 4-amino-3-bromo-1H-pyridin-2-one 4-Amino-3-bromo-2-hydroxypyridine 2(1H)-Pyridinone, 4-amino-3-bromo- |
| CAS | 107842-74-0 |
| InChI | InChI=1/C5H5BrN2O/c6-4-3(7)1-2-8-5(4)9/h1-2H,(H3,7,8,9) |
107842-74-0 - Physico-chemical Properties
| Molecular Formula | C5H5BrN2O |
| Molar Mass | 189.01 |
| Density | 1.826±0.06 g/cm3(Predicted) |
| Melting Point | 255-258 °C |
| Boling Point | 284.7±40.0 °C(Predicted) |
| Flash Point | 126°C |
| Vapor Presure | 0.00293mmHg at 25°C |
| pKa | 10.00±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.635 |
107842-74-0 - Introduction
4-Amino -3-bromopyridin-2-ol is an organic compound with the chemical formula C≡H≡BrN₂ O. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: 4-Amino-3-bromopyridin-2-ol is a white crystalline solid.
-Solubility: It is insoluble in water, but easily soluble in organic solvents such as ethanol and chloroform.
-Melting point: Its melting point is about 172-176°C.
-Flammability: 4-Amino-3-bromopyridin-2-ol is flammable at high temperatures.
Use:
4-amino -3-bromopyridin-2-ol has a wide range of uses in chemical synthesis:
-Pharmaceutical: It can be used to synthesize some drug intermediates or drug active structures.
-Pesticide: It can be used as a pesticide intermediate or a raw material for pesticide active ingredients.
-Others: It can also be used as a catalyst in organic synthesis reactions, the synthesis of transition metal coordination compounds, etc.
Preparation Method:
The synthesis method of 4-amino-3-bromopyridin-2-ol can be carried out by the following steps:
1. 3-bromopyridin-2-ol is reacted with acetone under alkaline conditions to obtain 3-bromopyridin-2-one.
2.3-bromopyridin-2-one is reacted with ammonia water to generate 4-amino -3-bromopyridin-2-one.
3. Finally, 4-amino -3-bromopyridin-2-one is reacted with a base to generate 4-amino -3-bromopyridin-2-ol.
Safety Information:
Nature:
-Appearance: 4-Amino-3-bromopyridin-2-ol is a white crystalline solid.
-Solubility: It is insoluble in water, but easily soluble in organic solvents such as ethanol and chloroform.
-Melting point: Its melting point is about 172-176°C.
-Flammability: 4-Amino-3-bromopyridin-2-ol is flammable at high temperatures.
Use:
4-amino -3-bromopyridin-2-ol has a wide range of uses in chemical synthesis:
-Pharmaceutical: It can be used to synthesize some drug intermediates or drug active structures.
-Pesticide: It can be used as a pesticide intermediate or a raw material for pesticide active ingredients.
-Others: It can also be used as a catalyst in organic synthesis reactions, the synthesis of transition metal coordination compounds, etc.
Preparation Method:
The synthesis method of 4-amino-3-bromopyridin-2-ol can be carried out by the following steps:
1. 3-bromopyridin-2-ol is reacted with acetone under alkaline conditions to obtain 3-bromopyridin-2-one.
2.3-bromopyridin-2-one is reacted with ammonia water to generate 4-amino -3-bromopyridin-2-one.
3. Finally, 4-amino -3-bromopyridin-2-one is reacted with a base to generate 4-amino -3-bromopyridin-2-ol.
Safety Information:
Last Update：2024-04-09 21:00:56
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CAS: 107842-74-0
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CAS: 107842-74-0
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Email: 3008007409@qq.com
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