108-16-7
1-Dimethylamino-2-propanol
CAS: 108-16-7
Molecular Formula: C5H13NO
108-16-7 - Names and Identifiers
108-16-7 - Physico-chemical Properties
| Molecular Formula | C5H13NO |
| Molar Mass | 103.16 |
| Density | 0.913g/mLat 25°C |
| Melting Point | -85 °C |
| Boling Point | 96°C |
| Flash Point | 96°F |
| Water Solubility | miscible |
| Vapor Presure | 8 mm Hg ( 20 °C) |
| Vapor Density | 3.6 (vs air) |
| Appearance | Liquid |
| Color | Clear colorless to yellow |
| BRN | 1209244 |
| pKa | 14.95±0.20(Predicted) |
| PH | 11 (100g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Flammable. Incompatible with strong oxidizing agents, amines, acids. |
| Sensitive | Air Sensitive |
| Explosive Limit | 2.7-11.1%(V) |
| Refractive Index | n20/D 1.42 |
| Physical and Chemical Properties | Density 0.837 melting point -40°C boiling point 121-127°C refractive index 1.4183-1.4203 flash point 35°C water-soluble miscible |
| Use | Used in the pharmaceutical industry and also as a stabilizer for acrylonitrile polymers |
108-16-7 - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R10 - Flammable R22 - Harmful if swallowed R34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. S23 - Do not breathe vapour. |
| UN IDs | UN 2734 8/PG 2 |
| WGK Germany | 1 |
| RTECS | UB3150000 |
| FLUKA BRAND F CODES | 10-34 |
| TSCA | Yes |
| HS Code | 29221980 |
| Hazard Class | 8 |
| Packing Group | II |
| Toxicity | LD50 orally in Rabbit: 1360 mg/kg |
108-16-7 - Nature
Open Data Verified Data
colorless liquid with ammonia odor. Relative density 0. 8645(20 ℃), melting point -85 ℃, boiling point 125.8 ℃, refractive index 1.4189, flash point 35 ℃. Soluble in water and alcohol.
Last Update：2025-06-10 22:55:16
108-16-7 - Preparation Method
Open Data Verified Data
- The propylene oxide method is derived from the reaction of propylene oxide with dimethylamine.
- chloroisopropanol method.
Last Update：2022-01-01 10:35:33
108-16-7 - Application
Open Data Verified Data
It is used as an intermediate of promethazine and mesalgia, and also as a stabilizer of acrylonitrile polymer.
Last Update：2025-08-19 16:24:40
108-16-7 - Safety
Open Data Verified Data
- This product can stimulate the skin and lungs. Contact with the eyes can produce severe irritation. Respiratory tract inhalation can cause Nausea, Head Pain and bronchitis, mental confusion, confusion, occasional convulsions; Digestive tract intake can cause Nausea, Vomit, severe hematemesis, and have the symptoms of confusion, mental confusion, convulsions may occur.
- packaged in 250kg iron drum. Store in a cool, ventilated room, away from fire and heat sources, to prevent direct sunlight. With acid, oxidant Isolation storage.
Last Update：2025-06-10 22:55:16
108-16-7 - Reference Information
| LogP | -0.12 at 23℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | It is used as an intermediate for the drug promethazine, mesalgia. It is also used as a stabilizer for acrylonitrile polymers. Chlorination of 1-dimethylamino-2-propanol with thionyl chloride yields 2-chloro-1-dimethylaminopropane hydrochloride [584-49-0]. used in the pharmaceutical industry and also as a stabilizer for acrylonitrile polymers |
| production method | 1. The propylene oxide method is obtained by reacting propylene oxide with dimethylamine. The chloroisopropanol method consists of the reaction of chloroisopropanol with dimethylamine. |
| category | flammable liquid |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 1890 mg/kg |
| stimulation data | Skin-rabbits 10 mg/24 h mild; eye-rabbit 500 mg/4 S severe |
| flammability hazard characteristics | flammable in case of open flame, high temperature and oxidant; toxic NOx smoke from combustion |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from the oxidant |
| extinguishing agent | dry powder, dry sand, carbon dioxide, foam, 1211 extinguishing agent |
| autoignition temperature | 225°C |
Last Update：2024-04-10 22:29:15
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