108-91-8

108-91-8 - Names and Identifiers

Name	Cyclohexylamine
Synonyms	CHA Cyclohexylamine cyclohexanamine Aminocyclohexane Hexahydroaniline 1-Cyclohexylamine 1-Aminocyclohexane Aniline, hexahydro- aminocyclohexane[qr] Aminohexahydrobenzene Benzenamine, hexahydro- aminohexahydrobenzene[qr] benzenamine,hexahydro-[qr]
CAS	108-91-8
EINECS	203-629-0
InChI	InChI=1/C6H13N/c7-6-4-2-1-3-5-6/h6H,1-5,7H2
InChIKey	PAFZNILMFXTMIY-UHFFFAOYSA-N

108-91-8 - Physico-chemical Properties

Molecular Formula	C6H13N
Molar Mass	99.17
Density	0.867g/mLat 25°C(lit.)
Melting Point	-17 °C
Boling Point	134°C(lit.)
Flash Point	90°F
Water Solubility	MISCIBLE
Solubility	organic solvents: miscible
Vapor Presure	10 mm Hg ( 22 °C)
Vapor Density	3.42 (vs air)
Appearance	Liquid
Color	Clear
Exposure Limit	TLV-TWA 10 ppm (～40 mg/m3) (ACGIH).
Merck	14,2729
BRN	471175
pKa	10.66(at 24℃)
PH	11.5 (100g/l, H2O, 20℃)
Storage Condition	Store below +30°C.
Sensitive	Air Sensitive
Explosive Limit	1.6-9.4%(V)
Refractive Index	n20/D 1.459(lit.)
Physical and Chemical Properties	Melting Point:-17.7 ℃ Boiling Point: 134.5 ℃ relative density (water = 1):0.86 saturated vapor pressure (kpa) 1.17(25 ℃) refractive index: 1.4585 solubility: soluble in water, miscible in most organic solvents
Use	It is used in the manufacture of reactive dyes, softeners VS and pharmaceuticals, and can also be used in pharmaceuticals and pesticides.

108-91-8 - Risk and Safety

Risk Codes	R10 - Flammable R21/22 - Harmful in contact with skin and if swallowed. R34 - Causes burns R62 - Possible risk of impaired fertility R24 - Toxic in contact with skin R22 - Harmful if swallowed
Safety Description	S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S1/2 - Keep locked up and out of the reach of children. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
UN IDs	UN 2357 8/PG 2
WGK Germany	1
RTECS	GX0700000
FLUKA BRAND F CODES	10-34
TSCA	Yes
HS Code	2921 30 10
Hazard Class	8
Packing Group	II
Toxicity	LD50 orally in rats: 0.71 ml/kg (Smyth)

108-91-8 - Upstream Downstream Industry

Raw Materials

Ethanolamine

108-91-8 - Nature

Open Data Verified Data

colorless or light yellow liquid. Fishy smell. Strong alkaline, soluble in water, ethanol, ether, acetone, esters, hydrocarbons and other organic reagents. By high thermal decomposition. Release of toxic gases, and the oxidant reaction. It is flammable in case of open flame and high heat. A strong reaction with an oxidizing agent can occur.

Last Update：2025-06-10 22:55:16

108-91-8 - Preparation Method

Open Data Verified Data

It is obtained by catalytic reduction of aniline at high temperature and high pressure using nickel or cobalt as a catalyst. It is also possible to obtain cyclohexanol by catalytic reduction of phenol, which is oxidized to cyclohexanone, and then aminated with ammonia to obtain cyclohexylamine.

Last Update：2025-06-10 22:55:16

108-91-8 - Application

Open Data Verified Data

used as a boiler feed water pH regulator. Cyclohexylamine is a volatile substance, and it can easily reach the whole system after dosing. If the pH is lower than 8.5, the effect of the cyclohexylamine treatment is disadvantageous.

Last Update：2025-08-19 16:24:40

108-91-8 - Safety

Open Data Verified Data

rat oral LD50: 710mg/kg; Rabbit percutaneous LD50: 227mg/kg. Inhalation of vapor can occur acute poisoning. It is irritant and corrosive to skin, eyes and mucous membranes, and can cause allergy through skin absorption. If splash into the eyes or contact the skin, apply a lot of water rinse. The allowable mass concentration in air is 40mg/ma in the United States. Should be associated with oxidant, heat source Isolation. Store in a cool, ventilated warehouse. Keep away from fire and heat source. Protection from direct sunlight. Keep the container sealed. Should be stored separately from oxidants and acids.

Last Update：2022-01-01 09:30:27

108-91-8 - Reference Information

freezing point	-17.7 ℃
LogP	3.7 at 25℃
NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Introduction	cyclohexylamine is a colorless transparent liquid with strong fishy and ammonia odor. Flammable. Soluble in water, with ethanol, ether, acetone, ethyl acetate, chloroform, heptane, benzene and other general organic solvents miscible. Cyclohexylamine can volatilize with water vapor. Can absorb carbon dioxide in the air, the formation of white crystalline carbonate. An azeotrope is formed with water, with a azeotropic point of 96.4 °c and a water content of 55.8%. The aqueous solution is alkaline. 0.01% concentration of aqueous solution pH = 10.5. Its vapor forms an explosive mixture with air.
Main purpose	cyclohexylamine can be used as raw material of surfactant to produce cyclohexylbenzene sulfonate, used as emulsifier and foaming agent; perfume raw materials to produce allyl cyclohexyl propionate; Dye raw materials to produce acid blue 62, disperse fluorescent yellow, disperse fluorescent yellow H5GL, weak acid blue BRN, Disperse Blue 6 and dye auxiliaries; The raw material of food additive sweet material; Cyclohexylamine can be used to produce cyclohexylamine sulfonate and sodium cyclamate, which is a sweetener 30 times higher than sucrose sweetness, trade name cyclamate, china's Ministry of Health approved for pickles, sauces, wine, cakes, biscuits, bread, frozen drinks, beverages, the maximum use of 0.65g/kg. raw materials for pesticides, pesticides used in the production of fruit trees "acaraptor", herbicide Wilber and fungicides; Additives used in the preparation of petroleum products, boiler water treatment agents and corrosion inhibitors; raw material of rubber vulcanization accelerator to produce thiazole vulcanization accelerator CZ, which has excellent vulcanization performance and is especially suitable for SBR and FDA rubber. Used as rust inhibitor, production of anti-rust paper; Clearing agent; Antifreeze; antistatic agents (Textile Auxiliaries), latex coagulants and additives for petroleum products; Due to the alkalinity of cyclohexylamine aqueous solution, it can be used as an absorbent for CO2 removal and sulfur dioxide removal.
preparation method	can be catalyzed by aniline at high temperature and high pressure (nickel or cobalt) reduction to produce cyclohexylamine product; Can also be obtained from phenol by catalytic reduction of cyclohexanol, cyclohexanone as raw materials, and ammonia amination.
toxicity	This product is toxic and irritates the skin and mucous membranes, causing gangrene, but it does not cause blood poisoning. Rat oral LD50710mg/kg. The maximum allowable concentration in the workplace is 10 x 10-6.
Use	used as rubber vulcanization accelerator, also used as synthetic fiber, dye, vapor phase corrosion inhibitor raw material used in the manufacture of reactive dyes, softeners VS and medicine Crestor thionite, and so on, can also be used in medicine, pesticide. cyclohexylamine is an intermediate of the herbicide cycloazinone, and also an intermediate of rubber accelerator, petroleum additive and corrosion inhibitor. This product is used to prepare cyclohexanol, cyclohexanone, caprolactam, cellulose acetate and Nylon 6, etc. Cyclohexylamine itself as a solvent, can be used in resin, coating, fat, paraffin oil applications. It can also be used for the preparation of desulfurizer, rubber antioxidant, vulcanization accelerator, plastic and textile chemical additives, boiler water treatment agent, metal corrosion inhibitor, emulsifier, preservative, antistatic agent, latex coagulant, petroleum additive, bactericide, pesticide and dye intermediates. Sulfonates of cyclohexylamine, used in food, beverage, and medicine as an artificial flavor. used in organic synthesis, plastic synthesis, also as preservatives and acid gas absorbents intermediates for the production of water treatment chemicals, artificial sweeteners, rubber processing chemicals and agrochemicals. acid gas absorbent, organic synthesis.
production method	is obtained by catalytic hydrogenation of aniline, and can be divided into atmospheric pressure method and pressure method. In addition, cyclohexylamine can be obtained by catalytic aminolysis of cyclohexane or cyclohexanol, reduction of nitrocyclohexane, and catalytic aminolysis of cyclohexanone in the presence of hydrogen. The preparation method is obtained by using aniline as a raw material through catalytic hydrogenation. The aniline vapor is mixed with hydrogen and then enters the catalytic reactor, and the hydrogenation reaction is carried out at 130~170 ° C. In the presence of cobalt catalyst. After cooling, the product is distilled to obtain a finished product.
category	flammable liquid
toxicity grade	high toxicity
Acute toxicity	oral-rat LD50: 156 mg/kg; Oral-mouse LD50: 224 mg/kg
stimulation data	Skin-rabbits 2 mg/24 h mild; eye-rabbit 0.05 mg/24 h severe
explosive hazard characteristics	explosive when mixed with air
flammability hazard characteristics	flammable in case of open flame, high temperature and oxidant; toxic NOx smoke from combustion
storage and transportation characteristics	The warehouse is ventilated and dried at low temperature; Stored separately from oxidants and acids
extinguishing agent	dry powder, dry sand, carbon dioxide, foam, 1211 extinguishing agent
Occupational Standard	TWA 40 mg/m3
spontaneous combustion temperature	559 ° F.
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)

Last Update：2024-04-09 02:00:04

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108-91-8

Cyclohexylamine

CAS: 108-91-8

Molecular Formula: C6H13N

108-91-8 - Names and Identifiers

108-91-8 - Physico-chemical Properties

108-91-8 - Risk and Safety

108-91-8 - Upstream Downstream Industry

108-91-8 - Nature

Open Data Verified Data

108-91-8 - Preparation Method

Open Data Verified Data

108-91-8 - Application

Open Data Verified Data

108-91-8 - Safety

Open Data Verified Data

108-91-8 - Reference Information

Supplier List

108-91-8 Request for Quotation

Cyclohexylamine

CAS: 108-91-8

Molecular Formula: C6H13N

108-91-8 - Names and Identifiers

108-91-8 - Physico-chemical Properties

108-91-8 - Risk and Safety

108-91-8 - Upstream Downstream Industry

108-91-8 - Nature

Open Data Verified Data

108-91-8 - Preparation Method

Open Data Verified Data

108-91-8 - Application

Open Data Verified Data

108-91-8 - Safety

Open Data Verified Data

108-91-8 - Reference Information

Supplier List

108-91-8