108885-68-3
Taccalonolide A
CAS: 108885-68-3
Molecular Formula: C36H46O14
108885-68-3 - Names and Identifiers
108885-68-3 - Physico-chemical Properties
| Molecular Formula | C36H46O14 |
| Molar Mass | 702.74 |
| Density | 1.41±0.1 g/cm3 (20 ºC 760 Torr) |
| Boling Point | 776.8±60.0 °C(Predicted) |
| Specific Rotation(α) | (c, 0.025 in CHCl3)+39.5 |
| Solubility | Insuluble (1.3E-3 g/L) (25 °C) |
| Appearance | Powder |
| pKa | 11.56±0.70(Predicted) |
| Storage Condition | 2-8℃ |
108885-68-3 - Reference Information
| biological activity | Taccalonolide A is a microtubule stabilizer, a steroid isolated from Tacca chantrieri, with cytotoxicity and antimalarial activity. Taccalonolide A can cause G2-M phase retention, Bcl-2 phosphorylation and apoptosis. Taccalonolide A has significant inhibitory effect on cell lines overexpressing p glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7) in vitro, and the IC50 value of inhibiting SK-OV-3 cell growth is 622 nM. |
| target | microtubule |
Last Update：2024-04-09 02:00:01
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