109-01-3
1-Methylpiperazine
CAS: 109-01-3
Molecular Formula: C5H12N2
109-01-3 - Names and Identifiers
| Name | 1-Methylpiperazine |
| Synonyms | NMPRZ Methylpiperazine 1-methyl-piperazin N-METHYLPIPERAZINE 1-Methylpiperazine 4-Methylpiperazine N-Methyl piperazine 1-Methyl piperazine 1-methylpiperazinediium Cyclizine Related CoMpound A 1-METHYLPIPERAZINE FOR SYNTHESIS |
| CAS | 109-01-3 |
| EINECS | 203-639-5 |
| InChI | InChI=1/C5H12N2/c1-7-4-2-6-3-5-7/h6H,2-5H2,1H3/p+2 |
| InChIKey | PVOAHINGSUIXLS-UHFFFAOYSA-N |
109-01-3 - Physico-chemical Properties
| Molecular Formula | C5H12N2 |
| Molar Mass | 100.16 |
| Density | 0.903g/mLat 25°C(lit.) |
| Melting Point | -6 °C |
| Boling Point | 138°C(lit.) |
| Flash Point | 108°F |
| Water Solubility | soluble |
| Solubility | Chloroform (Soluble), Methanol (Soluble) |
| Vapor Presure | 12 hPa (20 °C) |
| Vapor Density | 3.5 (vs air) |
| Appearance | Liquid |
| Specific Gravity | 0.903 |
| Color | Clear |
| BRN | 102724 |
| pKa | pK1:4.94(+2);pK2:9.09(+1) (25°C,μ=0.1) |
| PH | 11-12 (50g/l, H2O, 20℃) |
| Storage Condition | 2-8°C |
| Sensitive | Hygroscopic |
| Explosive Limit | 1.2-9.9%(V) |
| Refractive Index | n20/D 1.466(lit.) |
| Physical and Chemical Properties | Colorless liquid. Boiling point 138 ℃(140 ℃), relative density 0.903(20/4 ℃), refractive index 1.4378, flash point 42 ℃, soluble in water, ether, ethanol, water, methanol and other arbitrary ratio of mutual solubility, in aqueous solution is weak alkaline. |
| Use | For the preparation of antibacterial drugs mepivacaine, antipsychotic drugs such as trifluoperazine and Ofloxacin |
109-01-3 - Risk and Safety
| Risk Codes | R10 - Flammable R21 - Harmful in contact with skin R23 - Toxic by inhalation R34 - Causes burns R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21 - Harmful by inhalation and in contact with skin. |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. |
| UN IDs | UN 2734 8/PG 2 |
| WGK Germany | 2 |
| RTECS | TM1225000 |
| TSCA | Yes |
| HS Code | 29335995 |
| Hazard Note | Flammable/Toxic/Corrosive/Store under nitrogen |
| Hazard Class | 3 |
| Packing Group | III |
| Toxicity | LD50 orally in Rabbit: 2547 mg/kg LD50 dermal Rabbit 1341 mg/kg |
109-01-3 - Upstream Downstream Industry
| Raw Materials | Methyl alcohol Piperazine |
| Downstream Products | clozapine |
109-01-3 - Nature
Open Data Verified Data
colorless transparent liquid with strong ammonia odor. It is easy to oxidize and change color at high temperature. Boiling point 138 C (140 C). Relative density 0.903 (20/4 C). Refractive index 1. 4378. Flash point 42. Soluble in water, ethyl ether, ethanol, and water, methanol and other arbitrary ratio of mutual solubility, in aqueous solution is weak alkaline.
Last Update：2025-06-10 22:55:16
109-01-3 - Preparation Method
Open Data Verified Data
obtained from the methylation reaction of piperazine hexahydrate. Piperazine hexahydrate and hydrochloric acid were added to the reaction pot, heated to 45 °c, and a mixture of formic acid and formaldehyde was added dropwise. After completion of the addition, the reaction was carried out at about 50 ° C. For 2-3H, followed by heating and refluxing until carbon dioxide gas no longer escapes. It was cooled to 80 °c, hydrochloric acid was added and the acid was heated to dryness. After being slightly cooled, methanol was added, heated to reflux for 30min, and filtered while hot (filter residue was piperazine dihydrochloride). Filtrate recovery of methanol to the end, the residue was added to a pH of 14 sodium hydroxide solution, distillation, aqueous methyl piperazine. Benzene was heated to reflux with water as much as possible, fractionated, and the 132~140 °c fraction was collected to obtain anhydrous methylpiperazine. The yield was about 50%.
Last Update：2022-01-01 10:53:37
109-01-3 - Application
Open Data Verified Data
intermediates in organic synthesis. In the pharmaceutical industry for the preparation of antibiotics drugs mepivacaine, antipsychotic drugs such as trifluoperazine. Mainly used as ofloxacin, clozapine, sildenafil, anti-TB, zopiclone and other drug intermediates, can also be used in pesticides, dyes, plastics and other industries.
Last Update：2025-08-19 16:24:40
109-01-3 - Reference Information
| LogP | -0.57 at 25℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | organic synthesis intermediates. In the pharmaceutical industry for the preparation of antibiotics drugs mepivacaine, antipsychotic drugs such as trifluoperazine. Mainly used as ofloxacin, clozapine, sildenafil, anti-TB, zopiclone and other drug intermediates, can also be used in pesticides, dyes, plastics and other industries. synthesis of nifuroperazone (also known as furan piperazine amide, Nifurpipone), trifluoperazine and other dozens of drugs organic synthesis, pharmaceutical, synthetic fiber and other intermediates. for the preparation of antibacterial drugs such as mepivacaine, antipsychotic trifluoperazine and ofloxacin |
| production method | is obtained from the methylation reaction of piperazine hexahydrate. Piperazine hexahydrate and hydrochloric acid were added to the reaction pot, heated to 45 °c, and a mixture of formic acid and formaldehyde was added dropwise. After completion of the addition, the reaction was carried out at about 50 ° C. For 2-3H, followed by heating and refluxing until carbon dioxide gas no longer evolved. It was cooled to 80 °c, hydrochloric acid was added and the acid was heated to dryness. After being slightly cooled, methanol was added, heated to reflux for 30min, and filtered while hot (filter residue was piperazine dihydrochloride). Methanol was recovered from the filtrate, and the residue was added to a sodium hydroxide solution to pH = 14, followed by distillation to obtain aqueous methylpiperazine. Benzene was heated and refluxed with water to the end, fractionated, and the 132-140 °c fraction was collected to obtain anhydrous methylpiperazine. The yield was about 50%. |
| autoignition temperature | 320°C |
Last Update：2024-04-09 20:52:54
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Raw Materials for 109-01-3
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