11018-89-6
Ouabain octahydrate
CAS: 11018-89-6
Molecular Formula: C29H60O20
11018-89-6 - Names and Identifiers
11018-89-6 - Physico-chemical Properties
| Molecular Formula | C29H60O20 |
| Molar Mass | 728.77 |
| Melting Point | 260 °C |
| Water Solubility | Soluble in water. |
| Solubility | H2O: 10 mg/mL cold |
| Appearance | powder |
| Color | white |
| BRN | 101712 |
| Storage Condition | room temp |
| Stability | Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| Sensitive | Light Sensitive |
| Physical and Chemical Properties | Bioactive Ouabain Octahydrate is a Na /K -ATPase inhibitor with potential for congestive heart failure research. |
| Use | Uses typical inhibitors of Na , K -ATPase, inhibiting cation transport. Cardiac glycoside. Biochemical studies |
11018-89-6 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R23/25 - Toxic by inhalation and if swallowed. R33 - Danger of cumulative effects |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 1544 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | RN3850000 |
| FLUKA BRAND F CODES | 8 |
| HS Code | 29389090 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
11018-89-6 - Nature
| EPA chemical substance information | Card-20(22)-enolide, 3-[(6-deoxy-.alpha.-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-, octahydrate, (1.beta.,3.beta.,5.beta.,11.alpha.)- (11018-89-6) |
Last Update：2024-04-10 22:29:15
11018-89-6 - Uses and methods of synthesis
in vitro studies
Ouabain (100 μM) induces NLRP3 inflammasome activation and IL-1β release in macrophages. Ouabain-induced NLRP3 inflammasome activation is mediated through K efflux. Ouabain (3 nM) alters the expression of EMT markers in NHK and ADPKD cells, and modifies cell-cell adhesion properties in ADPKD. Moreover, ouabain enhances migration of ADPKD cells selectively modulates tight junctions, and modulates adherens junctions in ADPKD cells in a selective manner. Ouabain also activates TGFβ-Smad3 signaling, alters TER in ADPKD cells. Ouabain (25, 50 or 100 nM) treatment significantly reduces cell proliferation and viability in Raji cells in a dose-dependent manner with IC 50 of 76.48±4.03 nM. Ouabain increases the number of apoptotic cells, induces autophagy, and upregulates Beclin-1 in Raji cells.
in vivo studies
Ouabain (3 mg/kg) significantly decreases cardiac contractile force with an enlarged LVESD when mice are primed with LPS. IL-1β deficiency attenuates ouabain-induced cardiac dysfunction and injury. IL-1β secreted by infiltrated macrophages contributes to ouabain-induced cardiac inflammation. Deficiency of NLRP3 and Casp1 attenuates ouabain-induced cardiac dysfunction and macrophage infiltration. Ouabain (30 µg/kg, I .p.) modulates ABCB1 activity in thymocytes of Wistar rats and it has the same effect on Swiss mice at 300 µg/kg. After 14 days of ouabain treatment, the MAP of rats is significantly elevated.
category
toxic substances
toxicity grade
highly toxic
Acute toxicity
intraperitoneal-mouse LD50: 1.213 mg/kg; Intravenous-mouse LD50: 3.750 mg/kg
flammability hazard characteristics
flammable, fire discharge spicy and stimulating smoke
storage and transportation characteristics
warehouse low temperature, ventilation, dry; Separate storage with food raw materials
fire extinguishing agent
water, carbon dioxide, dry powder, sand
Last Update：2024-04-09 20:15:17
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Spot supply
Product Name: Ouabain octahydrate Request for quotationCAS: 11018-89-6
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Ouabain octahydrate Visit Supplier Webpage Request for quotationCAS: 11018-89-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Strophantine Octahydrate Visit Supplier Webpage Request for quotationCAS: 11018-89-6
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
View History
11018-89-6
122-31-6
19789-60-7
51933-78-9
铬酸酐
Diethyl chlorophosphite
446-52-6
富马酸GS-7340
Irgacure 184
transparent yellow 3g
122-31-6
19789-60-7
51933-78-9
铬酸酐
Diethyl chlorophosphite
446-52-6
富马酸GS-7340
Irgacure 184
transparent yellow 3g