1103234-56-5

1103234-56-5 - Names and Identifiers

Name	2,6-Difluoro-3-[(propylsulfonyl)amino]benzoic acid
Synonyms	Difluoro-3-(propylsulfonaMido)benzoic acid 2,6-difluoro-3-(propylsulfonamido)benzoic acid 2,6-difluoro-3-[(propylsulfonyl)aMino]Benzoic acid 2,6-Difluoro-3-[(propylsulfonyl)amino]benzoic acid 2,6-Difluoro-3-[(propylsulphonyl)amino]benzoic acid 2,6-difluoro-3-(propane-1-sulfonylamino)benzoic acid N-(3-Carboxy-2,4-difluorophenyl)propane-1-sulphonamide 2,6-Difluoro-3-[[(propan-1-yl)sulfonyl]amino]benzoic acid 2,6-Difluoro-3-(propylsulfonamido)benzoic acid 2,6-Difluoro-3-[[(propan-1-yl)sulfonyl]amino]benzoic acid
CAS	1103234-56-5
EINECS	700-740-0

1103234-56-5 - Physico-chemical Properties

Molecular Formula	C10H11F2NO4S
Molar Mass	279.26
Density	1.518
Melting Point	205～208℃
Boling Point	394.5±52.0 °C(Predicted)
pKa	2.11±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Sensitive	Irritant
MDL	MFCD18157658
Use	Use Only Rofini (Vemurafenib) is a BRAF inhibitor approved in FDA2011 in the United States. It is mainly used for the treatment of advanced melanoma. Clinical studies have shown that the drug resistance of Verofenib is more prominent, and the condition is relieved in the first few months of application to patients.

1103234-56-5 - Upstream Downstream Industry

Downstream Products

1-PropanesulfonaMide, N-[3-[[5-broMo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-

1103234-56-5 - Overview

Vemurafenib is a BRAF inhibitor approved by the United States in FDA2011. It is mainly used for the treatment of advanced melanoma. Clinical studies have shown that the drug resistance of Verofenib is more prominent, and the condition is relieved in the first few months of application. However, in most cases, melanoma recurs in the following months. Therefore, it is gradually necessary to find verafenib sensitizers. Researchers in the industry have paid attention to the efficacy of verafenib. Some studies have found that phenformin has a sensitizing effect on verafenib. As a verafenib sensitizer; there are studies looking for verafenib sensitizer from natural drugs. The only Ro Fini intermediate is 2, 6-difluoro-3-(propylsulfonamide) benzoic acid, which is mainly used to synthesize Ro Fini

Last Update：2024-04-09 20:52:54

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