110429-35-1

110429-35-1 - Names and Identifiers

Name	Paroxetine HCl Hemihydrate
Synonyms	PAROXETINE-D4 HCL Paroxetine HCl Hemihydrate Paroxetine-D4 hydrochloride Paroxetine Hydrochloride (350 mg) paroxetine hydrochloride Hemihydrate PAROXETINE-D4 HCL kf-yuwen(at)kf-chem.com (-)-(3S,4R)-PAROXETINE HYDROCHLORIDE HEMIHYDRATE 1,3-benzodioxol-5-yl-[4-(4-fluorophenyl)-3-piperidinyl]methanol hydrochloride (3s-trans)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride Hemihydrate
CAS	110429-35-1
EINECS	000-000-0
InChI	InChI=1/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14?,17-;/m0./s1

110429-35-1 - Physico-chemical Properties

Molecular Formula	C19H17ClD4FNO3
Molar Mass	369.85
Melting Point	121-131 C
Boling Point	451.7℃ at 760mmHg
Solubility	Slightly soluble in water, freely soluble in methanol, sparingly soluble in ethanol (96 per cent) and in methylene chloride.
Appearance	powder
Color	white
Maximum wavelength(λmax)	292nm(H2O)(lit.)
Merck	14,7043
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Use	This product is for scientific research only and shall not be used for other purposes.
In vitro study	Paroxetine (1 μM and 10 μM) distinctly restrains T cell migration induced by CX3CL1 through inhibiting GRK2. Paroxetine inhibits GRK2 induced activation of ERK. Paroxetine (10 μM) reduces pro-inflammatory cytokines in LPS-stimulated BV2 cells. Paroxetine (0-5 μM) leads to a dose-dependent inhibition on LPS-induced production of TNF-α and IL-1β in BV2 cells. Paroxetine also inhibits lipopolysaccharide (LPS)-induced nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in BV2 cells. Paroxetine (5 μM) blocks LPS-induced JNK activation and attenuates baseline ERK1/2 activity in BV2 cells. Paroxetine relieves microglia-mediated neurotoxicity, and suppresses LPS-stimulated pro-inflammatory cytokines and NO in primary microglial cells.
In vivo study	Paroxetine treatment obviously attenuates the symptoms of CIA rats. Paroxetine treatment clearly prevents the histological damage of joints and alleviates T cells infiltration into synovial tissue. Paroxetine reveals a strong effect on inhibiting CX3CL1 production in synovial tissues. Paroxetine (20 mg/kg/day) reduces the myocyte cross-sectional area in rat and ROS formation in the remote myocardium. Paroxetine reduces the susceptibility to ventricular tachycardia. Paroxetine treatment following MI decreases LV remodeling and susceptibility to arrhythmias, probably by reducing ROS formation. In CCI paroxetine-treated group, paroxetine (10 mg/kg, i.p.) produces hyperalgesia at days 7 and 10 (P<0.01), but a decrease in pain behavior is seen at day 14. Moreover, paroxetine (10 mg/kg) significantly attenuates tactile hypersensitivity when compared to CCI vehicle-treated group.

110429-35-1 - Risk and Safety

Risk Codes	R11 - Highly Flammable R34 - Causes burns R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed
Safety Description	S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing.
UN IDs	UN 3077 9 / PGIII
WGK Germany	3
RTECS	TM4569320
HS Code	29349990
Hazard Class	IRRITANT

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