110623-72-8
Epimedin A
CAS: 110623-72-8
Molecular Formula: C39H50O20
110623-72-8 - Names and Identifiers
| Name | Epimedin A |
| Synonyms | Epmedin A Epimedin A EPIMEDIN A TIANFUCHEM Epimedin A 4H-1-Benzopyran-4-one,3-[(6-deoxy-2-O-β-D-glucopyranosyl-α-L-mannopyranosyl)oxy]-7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)- 3-{[6-deoxy-2-O-(beta-D-glucopyranosyl)-alpha-L-mannopyranosyl]oxy}-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside (6-Deoxy-3-O-beta-D-glucopyranosyl-alpha-L-Mannopyranosyl)oxy]-7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-Methoxyphenyl)-8-(3-Methyl-2-buten-1-yl)-4H-1-benzopyran-4-one |
| CAS | 110623-72-8 |
| InChI | InChI=1/C39H50O20/c1-14(2)5-10-18-20(54-37-31(50)28(47)25(44)21(12-40)55-37)11-19(42)23-27(46)35(33(57-34(18)23)16-6-8-17(52-4)9-7-16)58-39-36(30(49)24(43)15(3)53-39)59-38-32(51)29(48)26(45)22(13-41)56-38/h5-9,11,15,21-22,24-26,28-32,36-45,47-51H,10,12-13H2,1-4H3/t15-,21+,22+,24-,25+,26+,28-,29-,30+,31+,32+,36+,37+,38-,39-/m0/s1 |
110623-72-8 - Physico-chemical Properties
| Molecular Formula | C39H50O20 |
| Molar Mass | 838.8 |
| Density | 1.61±0.1 g/cm3(Predicted) |
| Melting Point | 197-199 °C(Solv: methanol (67-56-1)) |
| Boling Point | 1099.8±65.0 °C(Predicted) |
| Flash Point | 333.188°C |
| Solubility | Methanol : 62.5 mg/mL (74.51 mM; Need ultrasonic) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Brown yellow crystalline powder |
| pKa | 5.90±0.40(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.69 |
| MDL | MFCD30496681 |
| Physical and Chemical Properties | Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Epimedium. |
110623-72-8 - Risk and Safety
| HS Code | 29329990 |
110623-72-8 - Reference
| Reference Show more | 1. Yang Ru, Liu Congyan, Xu Ting, et al. Adsorption Characteristics of Five Macroporous Adsorption Resins on Total Flavonoids of Epimedium [J]. Chinese Journal of Experimental Prescription 2020 v.26(06):121-128. 2. Hong Yadan, Zhang Lingfeng, Pan Pingping, et al. Simultaneous Determination of Seven Components in Epimedium-Drynum Rhizoma Pair by HPLC [J]. Chinese Patent Medicine 2019 041(006):1316-1321. 3. Wang Yingzhe, Jiang Dacheng, Rong Road, Zodiac Jing Lei, Zhang Qiang, Weng Lili. Comparative Analysis of Flavonoids in Epimedium Korea from Northeast China [J]. Journal of Pharmaceutical Analysis 2019 39(11):2034-2040. 4. Liu Cong Yan Gao Xia Chen Yan et al. Feasibility Study on Improving Oral Bioavailability of Total Flavonoids of Epimedium by Bionic Enzymatic Hydrolysis Enteric-coated Capsules [J]. China Journal of Pharmaceutical Industry 2016(9):1158-1164. 5. Li Jing, Wang Yingzhe, Liu Yucui, Jing Zhixian, Yan Li, Guo Junjie, Jiang Dacheng, Xiao Jinglei. Detection and Analysis of Effects of Geographical Environmental Factors on Spatial Distribution of Flavonoids in Epimedium Korea [J]. Chinese Journal of Traditional Chinese Medicine, 2019,44(24):5368-5374. 6. Zhang Yan. Separation and Purification of Epimedium EF5 Flavonoids by Macroporous Adsorption Resin [J]. Northern Pharmacy, 2015, 000(011):11-13. 7. Liu Congyan, Gao Xia, Huang Mengmeng, et al. Preparation and Evaluation of Epimedium Total Flavonoids Biomimetic Enzymatic Hydrolysis Enteric-coated Capsules [J]. Chinese Herbal Medicine, 2016(20). 8. Liu congyan, Gao Xia, Chen Yan, et al. pharmacokinetic behavior of total flavonoids of epimedium in osteoporotic rats [J]. Chinese patent medicine, 2017, 39(008):1595-1600. 9. Gao Xia, Liu Xuan, Chen Yan, et al. biotransformation process analysis of total flavonoids of epimedium [J]. Chinese journal of traditional Chinese medicine, 2013, 38(23):4079. 10. Gao Xia, Chen Yan, Wang Ying, et al. Effect of Dextrin Wet Granulation on Enzymatic Hydrolysis of Total Flavonoids from Epimedium [J]. Chinese Patent Medicine, 2014, 36(007):1392-1397. 11. Peng Jing, Ma Yihua, Chen Yan, et al. Simultaneous Biotransformation of Four Flavonoid Glycosides from Epimedium [J]. Chinese Patent Medicine, 2016, 38(9):1984-1990. 12. Wu Yanyan, Ren Hui Xu, Feng Youlong, Zhang Li, Zhang Yulin. HPLC Fingerprint of Anshen Bunao Capsule and Determination of Three Components [J]. Journal of Guangdong Pharmaceutical University, 2020,36(06):778-783. 13. Xu Ting, Huang Mengmeng, Li Ruiyun, Yang Ru, Liu Lifang, Chen Yan. Study on Quality Evaluation of Different Parts of Multi-base Primary Epimedium [J]. Chinese herbal medicine, 2020,51(01):190-196. 14. Lan Hai, Liu Xinyan, Yu Ling, Monolan, Zhang Yan, Guo Ziyou, Wu Qing. Purification of epimedium and icariin by macroporous resin [J]. Chinese herbal medicine, 2020,51(17):4473-4481. 15. [IF = 4.545] Yan-dan Zhou et al."Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway." Biomed Pharmacother. 2019 Jan;109:2309 16. [IF = 4.411] Zhenxian Qin et al."A Widely Metabolomic Analysis Revealed Metabolic Alterations of Epimedium Pubescens Leaves at Different Growth Stages." Molecules. 2020 Jan;25(1):137 17. [IF = 4.36] Kun Shi et al."Epimedii Folium and Curculiginis Rhizoma ameliorate lipopolysaccharides-induced cognitive impairment by regulating the TREM2 signaling pathway." J Ethnopharmacol. 2022 Feb;284:114766 18. [IF = 3.757] Congyan Liu et al."Enhanced hydrolysis and antitumor efficacy of Epimedium flavonoids mediated by immobilized snailase on silica." Process Biochem. 2019 Nov;86:80 19. [IF = 3.361] Yuhao Zhang et al."An integrated approach for structural characterization of Gui Ling Ji by traveling wave ion mobility mass spectrometry and molecular network." Rsc Adv. 2021 Apr;11(26):15546-15556 20. [IF = 5.34] Dong Shao et al."Identification of the active compounds and functional mechanisms of Jinshui Huanxian formula in pulmonary fibrosis by integrating serum pharmacochemistry with network pharmacology." PHYTOMEDICINE. 2022 Jul;102:154177 |
110623-72-8 - Reference Information
| plant source: | epimedium |
| biological activity | Chaohuodin A (Epimedin A) is a natural compound extracted from herbal epimedium. |
| uses | Chaohuodin A can be used for administration before anesthesia to reduce gland secretion, tremor paralysis and motion sickness. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: It has the effects of tonifying kidney, dispelling wind and dampness, strengthening muscles and bones, and enhancing immunity. |
Last Update：2024-04-09 20:49:11
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