111025-46-8
Pioglitazone
CAS: 111025-46-8;105355-27-9
Molecular Formula: C19H20N2O3S
111025-46-8 - Names and Identifiers
111025-46-8 - Physico-chemical Properties
| Molecular Formula | C19H20N2O3S |
| Molar Mass | 356.44 |
| Density | 1.260±0.06 g/cm3(Predicted) |
| Melting Point | 183-184 C |
| Boling Point | 575.4±45.0 °C(Predicted) |
| Flash Point | 301.8°C |
| Solubility | DMSO (Slightly, Heated) |
| Vapor Presure | 3.03E-13mmHg at 25°C |
| Appearance | White to off-white solid. |
| Color | White to Off-White |
| pKa | 6.35±0.50(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Physical and Chemical Properties | Colorless needle-like crystals were obtained from dimethylformamide-water, melting point 183-184 °c. Pioglitazone Hydrochloride: C19H20N2O3S? HCl. [112529-15-4]. Colorless prismatic crystals were obtained from ethanol, melting point 193-194 °c. |
| Use | For the treatment of type (II) diabetes |
| In vitro study | Pioglitazone is metabolized primarily by CYP2C8 and secondarily by CYP3A4. |
| In vivo study | In mice with extensive anterior myocardial infarction, Pioglitazone significantly attenuated left ventricular (LV) cavity dilatation and dysfunction by echocardiography, as well as left ventricular end-diastolic pressure. Pioglitazone partially standardized left atrial DP/ DT (maximum) and DP/ DT (minimum), left ventricular systolic function, which was significantly reduced in MI mice. In both the striatum and the substantia nigra compacta of the MPTP model mice of Parkinson's disease, Pioglitazone causes a decrease in the activation of microglia and a decrease in the number of induced iNOS-positive cells and oligoglial fibrillary acidic protein-positive cells. Pioglitazone almost completely blocked the staining of TH-positive neurons by nitrotyosine, a marker of NO-mediated cell damage. Pioglitazone (about 20 mg/kg/day) attenuates MPTP-induced glial activation in the substantia nigra pars compacta (substantia nigra pars compacta) of the MPTP model Mouse of Parkinson's disease, and prevents the loss of dopaminergic cells. In the hippocampus and cortex of 10-month-old APPV717I transgenic mice, Pioglitazone caused a decrease in the number of activated microglia and active astrocytes. Pioglitazone treatment reduced the expression of the pro-inflammatory expressed enzymes cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Pioglitazone reduced beta-secretase-1 (BACE1) mRNA and protein levels, as well as levels of soluble Abeta1-42 peptides by 27%. |
111025-46-8 - Risk and Safety
| Risk Codes | R11 - Highly Flammable R34 - Causes burns |
| Safety Description | S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
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