1119022-51-4

1119022-51-4 - Names and Identifiers

Name	1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-ol
Synonyms	TIMTEC-BB SBB000154 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-ol 1H-Pyrazol-3-ol, 1-methyl-5-(trifluoromethyl)- 3-HYDROXY-1-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE 5-HYDROXY-2-METHYL-3-TRIFLUOROMETHYL-1H-PYRAZOLE 3-HYDROXY-1-METHYL-5-TRIFLUOROMETHYL-1H-PYRAZOLE 1-Methyl-5-(trifluoromethyl)-1,2-dihydro-3H-pyrazol-3-one
CAS	1119022-51-4
EINECS	622-911-8
InChI	InChI=1S/C5H5F3N2O/c1-10-3(5(6,7)8)2-4(11)9-10/h2H,1H3,(H,9,11)

1119022-51-4 - Physico-chemical Properties

Molecular Formula	C5H5F3N2O
Molar Mass	166.1
Density	1.3876 (estimate)
Melting Point	114-115 °C
BRN	3543409
pKa	7.35±0.70(Predicted)
Storage Condition	Sealed in dry,Room Temperature

1119022-51-4 - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R25 - Toxic if swallowed
Safety Description	S24/25 - Avoid contact with skin and eyes. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
UN IDs	UN 2811 6.1 / PGIII
WGK Germany	3
Hazard Class	IRRITANT

1119022-51-4 - Introduction

3-Hydroxy-1-methyl-5-trifluoromethyl-1H-pyrazole (abbreviated as TFP) is an organic compound with the following properties:

1. Appearance: TFP is a white crystalline solid.

2. Solubility: TFP is soluble in a variety of organic solvents, such as ethers, ketones and chlorinated hydrocarbons, but its solubility in water is low.

3. Stability: TFP is stable at room temperature, but it will be decomposed by heat.

The main uses of TFP are as follows:

1. Reagent: TFP can be used as a reagent in organic synthesis reactions to introduce trifluoromethyl groups.

2. Protecting group: TFP can be used as a protecting group for hydroxyl groups to prevent them from being undesirably changed in the reaction.

3. pesticide intermediates: TFP is an important intermediate for the synthesis of pesticides.

The preparation of TFP is generally carried out through the following steps:

1. Synthesis of difluoromethanoyl chloride (DFF): difluoroformic acid was reacted with thionyl chloride to generate difluoromethanoyl chloride.

2. Synthesis of TFP: TFP was obtained by reacting difluoromethylchloride with pyrazole and methanol.

When using TFP, you need to pay attention to its security information:

1. Wear appropriate personal protective equipment, such as lab gloves, goggles and protective clothing.

2. avoid contact with skin and eyes, if there is contact should immediately rinse with plenty of water.

3. try to avoid inhalation of its vapor, to ensure that the operation in a well-ventilated place.

4. TFP is irritating and should not be exposed to it for a long time.

5. Waste disposal shall be carried out in accordance with relevant laws and regulations.

Last Update：2024-04-09 21:21:28