112559-91-8
HYDROXY ITRACONAZOLE
CAS: 112559-91-8
Molecular Formula: C35H38Cl2N8O5
112559-91-8 - Names and Identifiers
112559-91-8 - Physico-chemical Properties
| Molecular Formula | C35H38Cl2N8O5 |
| Molar Mass | 721.63 |
| Density | 1.44±0.1 g/cm3(Predicted) |
| Melting Point | 76-78°C |
| Boling Point | 884.7±75.0 °C(Predicted) |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Pale Beige |
| pKa | 14.72±0.20(Predicted) |
| Storage Condition | -20°C Freezer |
| In vitro study | Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ). Although Hydroxy Itraconazole is also reported to have antifungal activity in vitro, its pharmacokinetics in humans has been studied less than that of ITZ. ITZ and Hydroxy Itraconazole have a triazole ring and inhibit CYP3A. Their half-lives can be extended by 26-60% with repeated administration compared to single administration. |
| In vivo study | The plasma concentration of Hydroxy Itraconazole is weakly dependent on the dose of ITZ, most likely because the process that forms Hydroxy Itraconazole is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and Hydroxy Itraconazole. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of Hydroxy Itraconazole. However, the pharmacokinetics of Hydroxy Itraconazole is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and Hydroxy Itraconazole are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view. |
112559-91-8 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.413 ml | 7.066 ml | 14.131 ml |
| 5 mM | 0.283 ml | 1.413 ml | 2.826 ml |
| 10 mM | 0.141 ml | 0.707 ml | 1.413 ml |
| 5 mM | 0.028 ml | 0.141 ml | 0.283 ml |
Last Update：2024-01-02 23:10:35
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View History
112559-91-8
2283-08-1
20845-92-5
4-Hydroxytoluene
2,4-DIAMINO-6-FLUOROPYRIMIDINE
CALCIUM D-SACCHARATE
2-methyleicosanoic acid
2283-08-1
20845-92-5
4-Hydroxytoluene
2,4-DIAMINO-6-FLUOROPYRIMIDINE
CALCIUM D-SACCHARATE
2-methyleicosanoic acid