114906-74-0
Ciwujiano side C3
CAS: 114906-74-0
Molecular Formula: C53H86O21
114906-74-0 - Names and Identifiers
114906-74-0 - Physico-chemical Properties
| Molecular Formula | C53H86O21 |
| Molar Mass | 1059.25 |
| Density | 1.43±0.1 g/cm3(Predicted) |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
| Appearance | White crystalline powder |
| pKa | 12.50±0.70(Predicted) |
| Storage Condition | 2-8℃ |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, comes from Acanthopanax senticosus Acanthopanax senticosus dried rhizome. |
| In vitro study | Cell Viability Assay Cell Line: RAW264.7 cells Concentration: 10 µM, 20 µM and 40µM Incubation Time: 24 hours Result: Has no effect on cell cytotoxicity and inhibits NO production Western Blot Analysis Cell Line: RAW264.7 cells Concentration: 10 µM, 20 µM and 40µM Incubation Time: 24 hours Result: Decreases p-ERK and p-JNK expression. RT-PCR Cell Line: RAW264.7 cells Concentration: 10 µM, 20 µM and 40µM Incubation Time: 24 hours Result: Decreased COX-2 and iNOS mRNA expression in a dose-dependent manner. |
| In vivo study | Animal Model: Mice Dosage: 0.5 mg/kg Administration: Oral administration; 0.5 mg/kg/day; 17 days Result: Reinforced object recognition memory. |
114906-74-0 - Reference Information
| biological activity | Ciwujianoside C3 is an orally active compound that can penetrate the blood-brain barrier, isolated from the leaves of acanthopanax. Ciwujianoside C3 has an anti-inflammatory effect and can enhance the recognition memory of individual mice. |
| in vitro study | Cell viabilityassay Cell Line: RAW264.7 cells Concentration: 10 µm, 20 µm and 40 μm invasion Time: 24 hours Result: Has no effect on cell cytotoxicity and intests NO production Western Blot Analysis Cell Line: RAW264.7 cells Concentration: 10 µm, 20 µm and 40 μm Incubation Time: 24 hours Result: Decreases p-ERK and p-JNK expression. RT-PCR Cell Line: RAW264.7 cells Concentration: 10 µM, 20 µM and 40µM Incubation Time: 24 hours Result: Decreased COX-2 and iNOS mRNA expression in a dose-dependent manner. |
| Cell Line: | RAW264.7 cells RAW264.7 cells RAW264.7 cells |
| Concentration: | 10 µM, 20 µM and 40µM 10 µM, 20 µM and 40µM 10 µM, 20 µM and 40µM |
| Incubation Time: | 24 hours 24 hours 24 hours |
| Result: | Has no effect on cell cytotoxicity and inhibits NO production Decreases p-ERK and p-JNK expression. Decreased COX-2 and iNOS mRNA expression in a dose-dependent manner. Reinforced object recognition memory. |
| in vivo study | Animal Model: Mice Dosage: 0.5 mg/kg Administration: Oral administration; 0.5 mg/kg/day; 17 days Result: informed object recognition memory. |
| Animal Model: | Mice |
| Dosage: | 0.5 mg/kg |
| Administration: | Oral administration; 0.5 mg/kg/day; 17 days |
| Chemical properties | white crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, dried rhizomes derived from Acanthopanax senticosus. |
Last Update：2024-04-09 21:11:58
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