115532-50-8
TMRM [Tetramethylrhodamine, methyl ester, perchlorate]
CAS: 115532-50-8
Molecular Formula: C25H25ClN2O7
115532-50-8 - Names and Identifiers
115532-50-8 - Physico-chemical Properties
| Molecular Formula | C25H25ClN2O7 |
| Molar Mass | 500.93 |
| Melting Point | 274–276℃ |
| Solubility | DMSO: soluble |
| Appearance | crystals |
| Color | Dark green |
| Maximum wavelength(λmax) | 549 nm |
| BRN | 7162165 |
| Storage Condition | Sealed in dry,Room Temperature |
| MDL | MFCD00274460 |
| Use | Potential-Sensitive fluorescent probe for measuring membrane potential changes in mitochondria |
| In vitro study | TMRM Perchlorate is a fluorescent probe (excitation, 530±21 nm; emission, 592±22 nm). The fluorescence signal in the presence of TMRM Perchlorate shows a slight decrease after the addition of glutamate, indicative of increased polarization of the mitochondrial inner membrane. In the presence of TMRM Perchlorate (2 μM) the coupled respiration with Complex I substrates or upon the addition of Complex II substrate is decreased by 27%. Exposure of hippocampal cultures to low concentrations of TMRM Perchlorate (50 to 500 nM) for 1 to 3 hours results in selective staining of mitochondria in both neurons and the underlying glial cells. Exposure of hippocampal cultures to high concentrations of TMRM Perchlorate (1 to 25 µM) stains mitochondria selectively and quickly, reaching a plateau after 5 to 10 min. Low concentrations of TMRM Perchlorate (50 to 200 nM) do not induce apoptosis, whereas higher concentrations (0.5 and 2.5 µM) enhance apoptosis (K D = 500 nM). |
115532-50-8 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 8-10 |
115532-50-8 - Reference Information
| Biological activity | TMRM Perchlorate is a cell-permeable cationic lipophilic red fluorescent dye (λex = 530 nm, λem = 592 nm). |
| in vitro study | TMRM Perchlorate is a fluorescent probe (excitation, 530±21 nm; emission, 592±22 nm). The fluorescence signal in the presence of TMRM Perchlorate shows a slight decrease after the addition of glutamate, indicative of increased polarization of the mitochondrial inner membrane. In the presence of TMRM Perchlorate (2 μ M) the coupled respiration with Complex I substrates or upon the addition of Complex II substrate is decreased by 27%. Exposure of hippocampal cultures to low concentrations of TMRM Perchlorate (50 to 500 nm) for 1 to 3 hours results in selective staining of mitochondria in both neurons and the underlying glial cells. Exposure of hippocampal cultures to high concentrations of TMRM Perchlorate (1 to 25 m) stains mitochondria selectively and quickly, reaching a plateau after 5 to 10 min. Low concentrations of TMRM Perchlorate (50 to 200 nM) do not induce apoptosis, whereas higher concentrations (0.5 and 2.5 m) enhance apoptosis (K D = 500 nM). |
| biological field application | Detecting mitochondrial membrane potential; apoptosis assays; multidrug resistance assays |
Last Update：2024-04-10 22:29:15
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Product Name: TMRM Perchlorate Visit Supplier Webpage Request for quotationCAS: 115532-50-8
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Product Name: TMRM [Tetramethylrhodamine, methyl ester, perchlorate] Visit Supplier Webpage Request for quotation
CAS: 115532-50-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 115532-50-8
Tel: 18301782025
Email: 3008007409@qq.com
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