1162-65-8
Aflaloxin B1
CAS: 1162-65-8
Molecular Formula: C17H12O6
1162-65-8 - Names and Identifiers
| Name | Aflaloxin B1 |
| Synonyms | AFB1 CCRIS 12 HSDB 3453 NSC 529592 BRN 1269174 Aflaloxin B1 Aflatoxin B1 )(1)benzopyran-1,11-dione (6ar-cis)-ahydro-4-methoxy AFLATOXIN B1 FROM ASPERGILLUS FLAVUS AFLATOXIN B(1) FROM ASPERGILLUS FLAVUS, VIAL WITH 10 MG 1-Cyclopentene-1-carboxylic acid, 2-(3a,8a-dihydro-4-hydroxy-6-methoxyfuro[2,3-b]benzofuran-5-yl)-5-oxo-, delta-lactone |
| CAS | 1162-65-8 |
| EINECS | 214-603-3 |
| InChI | InChI=1/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3/t8-,17+/m0/s1 |
| InChIKey | OQIQSTLJSLGHID-WNWIJWBNSA-N |
1162-65-8 - Physico-chemical Properties
| Molecular Formula | C17H12O6 |
| Molar Mass | 312.27 |
| Density | 1.2810 (rough estimate) |
| Melting Point | 268-269 °C |
| Boling Point | 372.21°C (rough estimate) |
| Specific Rotation(α) | D -558° (c = 0.1 in CHCl3); D -480° (c = 0.1 in DMF) |
| Flash Point | 2°C |
| Water Solubility | 15mg/L(temperature not stated) |
| Solubility | Chloroform, dichloromethane |
| Vapor Presure | 3.05E-11mmHg at 25°C |
| Appearance | White to white-like |
| Merck | 13,180 |
| BRN | 1269174 |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. May be light or air sensitive. |
| Refractive Index | 1.4800 (estimate) |
| MDL | MFCD00869647 |
1162-65-8 - Risk and Safety
| Risk Codes | R45 - May cause cancer R46 - May cause heritable genetic damage R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable R65 - Harmful: May cause lung damage if swallowed R48/23/24/25 - R36/38 - Irritating to eyes and skin. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. S24 - Avoid contact with skin. S7 - Keep container tightly closed. S62 - If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label. S36/37 - Wear suitable protective clothing and gloves. S28 - After contact with skin, wash immediately with plenty of soap-suds. |
| UN IDs | UN 3462 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | GY1925000 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29322090 |
| Hazard Class | 6.1(a) |
| Packing Group | I |
| Toxicity | LD50 orally in day old duckling: 18.2 mg/50 gm body wt (Carnaghan); i.p. in newborn mice: 9.50 mg/kg body wt (Büchi) |
1162-65-8 - Reference
| Reference Show more | 1. Wang Chunyan, Jiang Xiaoqing, Zhou Bo Detection of aflatoxin B1 by electrochemical biosensor based on Cu TPA [J] Journal of Chemistry of Colleges and Universities, 2019, 40 (11). 2. Liu Ruoyun, Fu Chunni, Hu Tingting, Zheng Zhixun, Qin Shunyi. Effect of chitosan selenium on aflatoxin B feeding_ 1 Effects of growth and antioxidant function of mice [J]. Culture and Feed, 2020, 19 (08): 40-41. 3. Li Manxiu, Ren Guangming, Du Lijuan, et al Carbon quantum dots/silver composite for the detection of aflatoxin B1 in edible oil [J] Chinese oil, 2018, 43(4): 53-56. 4. He, B., Yan, X. An amperometric zearalenone aptasensor based on signal amplification by using a composite prepared from porous platinum nanotubes, gold nanoparticles and thionine-labelled graphene oxide. Microchim Acta 186, 383 (2019). https://doi.org/10.1 5. Zhao, Qiannan, et al. "Inhibitory Effects of Eurotium cristatum on Growth and Aflatoxin B1 Biosynthesis in Aspergillus flavus." Frontiers in Microbiology 11 (2020): 921.https://doi.org/10.3389/fmicb.2020.00921 6. Sun, Zhiwei, et al. "Functionalized nanoflower-like hydroxyl magnesium silicate for effective adsorption of aflatoxin B1." Journal of hazardous materials 387 (2020): 121792.https://doi.org/10.1016/j.jhazmat.2019.121792 7. Zhiming Sun, Ankang Song, Bin Wang, Gaofeng Wang, Shuilin Zheng,Adsorption behaviors of aflatoxin B1 and zearalenone by organo-rectorite modified with quaternary ammonium salts,Journal of Molecular Liquids,Volume 264,2018,Pages 645-651,ISSN 0167-7322 8. Baoshan He, Xiaohai Yan, A “signal-on” voltammetric aptasensor fabricated by hcPt@AuNFs/PEI-rGO and Fe3O4NRs/rGO for the detection of zearalenone, Sensors and Actuators B: Chemical, Volume 290, 2019, Pages 477-483, ISSN 0925-4005, https://doi.org/10.1016/j 9. Baoshan He, Xiaoze Dong, Nb.BbvCI powered DNA walking machine-based Zr-MOFs-labeled electrochemical aptasensor using Pt@AuNRs/Fe-MOFs/PEI-rGO as electrode modification material for patulin detection, Chemical Engineering Journal, Volume 405, 2021, 126642, 10. Wan, Xiaoli, et al. "Lycopene alleviates AFB1-induced liver damage possibly through inhibiting cytochrome 450 isozymes and improving Nrf2-miediated detoxi cation and antioxidant systems in broiler chickens." (2020). 11. [IF=6.057] Yongmei Jia et al."A label-free fluorescent aptasensor for the detection of Aflatoxin B1 in food samples using AIEgens and graphene oxide."Talanta. 2019 Jun;198:71 12. [IF=1.554] Pinzhu Qin et al."A potential reusable fluorescent aptasensor based on magnetic nanoparticles for ochratoxin A analysis."Open Chem. 2019 Jan;17(1):1301-1308 13. [IF=13.273] Baoshan He et al."Nb.BbvCI powered DNA walking machine-based Zr-MOFs-labeled electrochemical aptasensor using Pt@AuNRs/Fe-MOFs/PEI-rGO as electrode modification material for patulin detection."Chem Eng J. 2021 Feb;405:126642 14. [IF=10.618] Feng Hong et al."Highly sensitive magnetic relaxation sensing method for aflatoxin B1 detection based on Au NP-assisted triple self-assembly cascade signal amplification."Biosens Bioelectron. 2021 Nov;192:113489 15. [IF=10.588] Zhiwei Sun et al."Functionalized nanoflower-like hydroxyl magnesium silicate for effective adsorption of aflatoxin B1."J Hazard Mater. 2020 Apr;387:121792 16. [IF=9.038] Junpeng Zhao et al."Horseradish peroxidase-catalyzed formation of polydopamine for ultra-sensitive magnetic relaxation sensing of aflatoxin B1."J Hazard Mater. 2021 Jun;:126403 17. [IF=7.46] Baoshan He et al."A “signal-on” voltammetric aptasensor fabricated by hcPt@AuNFs/PEI-rGO and Fe3O4NRs/rGO for the detection of zearalenone."Sensor Actuat B-Chem. 2019 Jul;290:477 18. [IF=7.46] Long Wang et al."A DNAzyme-assisted triple-amplified electrochemical aptasensor for ultra-sensitive detection of T-2 toxin."Sensor Actuat B-Chem. 2021 Feb;328:129063 19. [IF=5.833] He Baoshan et al."An amperometric zearalenone aptasensor based on signal amplification by using a composite prepared from porous platinum nanotubes, gold nanoparticles and thionine-labelled graphene oxide."Microchim Acta. 2019 Jun;186(6):1-10 20. [IF=5.64] Zhao Qiannan et al."Inhibitory Effects of Eurotium cristatum on Growth and Aflatoxin B1 Biosynthesis in Aspergillus flavus."Front Microbiol. 2020 May;0:921 21. [IF=5.373] Han Yan et al."A label-free electrochemical immunosensing platform based on PEI-rGO/Pt@Au NRs for rapid and sensitive detection of zearalenone."Bioelectrochemistry. 2022 Feb;143:107955 22. [IF=3.352] X.L. Wan et al."Protective effects of lycopene on mitochondrial oxidative injury and dysfunction in the liver of aflatoxin B1-exposed broilers."Poultry Sci. 2021 Nov;100:101441 23. [IF=1.749] Md Touhiduzzaman Sarker et al."Evaluation of the protective effect of lycopene on growth performance, intestinal morphology, and digestive enzyme activities of aflatoxinB1 challenged broilers."Anim Sci J. 2021 Jan;92(1):e13540 24. [IF=2.752] Md Touhiduzzaman Sarker et al.Dietary Lycopene Supplementation Could Alleviate Aflatoxin B1 Induced Intestinal Damage through Improving Immune Function and Anti-Oxidant Capacity in Broilers.Animals-Basel. 2021 Nov;11(11):3165 25. [IF=7.312] Yan Li et al."Self-templating construction of flower-like mesoporous magnesium silicate composites from sepiolite for high-efficiency adsorption of aflatoxin B1."Sep Purif Technol. 2022 Jun;291:120953 26. [IF=1.559] Huang Tao et al."Effects of dietary supplementation with Ampelopsis grossedentata extract on production performance and body health of hens."Trop Anim Health Pro. 2022 Feb;54(1):1-14 27. [IF=2.217] Xiaoli Wan et al."Lycopene alleviates aflatoxin B1 induced liver damage through inhibiting cytochrome 450 isozymes and improving detoxification and antioxidant systems in broiler chickens."Ital J Anim Sci. 2022;21(1):31-40 28. [IF=3.591] Liangrui Lv et al."A switchable electrochemical hairpin-aptasensor for ochratoxin A detection based on the double signal amplification effect of gold nanospheres."New J Chem. 2022 Jan;: 29. [IF=4.098] Hongyan Zhang et al."Visual detection of aflatoxin B1 based on specific aptamer recognition combining with triple amplification strategy."Spectrochim Acta A. 2022 Jan;:120862 30. [IF=10.588] Rui Chen et al."Polydopamine nanoparticle-mediated, click chemistry triggered, microparticle-counting immunosensor for the sensitive detection of ochratoxin A."J Hazard Mater. 2022 Apr;428:128206 31. [IF=2.752] Fangju Liu et al."Resveratrol Relieved Acute Liver Damage in Ducks (Anas platyrhynchos) Induced by AFB1 via Modulation of Apoptosis and Nrf2 Signaling Pathways."Animals-Basel. 2021 Dec;11(12):3516 32. [IF=4.35] Sanjun Jin et al."Dietary Curcumin Alleviated Aflatoxin B1-Induced Acute Liver Damage in Ducks by Regulating NLRP3–Caspase-1 Signaling Pathways."Foods. 2021 Dec;10(12):3086 33. [IF=7.514] Supan Cheng et al."Surface-anchored liquid crystal droplets for the semi-quantitative detection of Aflatoxin B1 in food samples."FOOD CHEMISTRY. 2022 Oct;390:133202 |
1162-65-8 - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | aflatoxin (AFT) is a toxin produced by some strains such as aflatoxin and aspergillus parasiticus. In 1993, aflatoxin was designated as a naturally occurring carcinogen by the World Health Organization (WHO) Cancer Research Institute. The toxicity of aflatoxin is 68 times that of arsenic and 10 times that of potassium cyanide. It is extremely destructive to liver tissue. Data show that aflatoxin intake of 1 mg may cause cancer, and a single intake of 20 mg can be fatal. |
| source distribution | in daily life, agricultural and sideline products are more susceptible to aflatoxin-producing molds. For example, moldy peanuts, corn, wheat, spoiled rice, bitter nuts, small workshops self-extracting oil, long-soaked fungus, uncleaned chopping boards, etc. will have varying degrees of exposure to aflatoxin. Ordinary disinfection methods cannot eliminate aflatoxin at high temperature (100 degrees boiling water for 5 minutes). |
| toxicity | people have conducted a more in-depth study on its toxicity and found that its toxicity is extremely toxic. its severe toxicity is 10 times stronger than the well-known highly toxic potassium cyanide, even more toxic than the poison of cobra and golden ring snake, and 28-33 times stronger than the toxicity of highly toxic pesticides 1605 and 1059, A severely moldy corn containing 40 μg of aflatoxin can cause two ducklings to die. |
| detection method | currently, the main methods for separation and quantitative detection of AFB1 include thin layer chromatography, high performance liquid chromatography, liquid chromatography-tandem mass spectrometry and immunoassay. Most of these methods require bulky and expensive testing equipment, and the operation steps are complicated and the testing cycle is long, which is not conducive to on-site real-time testing. Therefore, the development of a method based on blood glucose meter detection of aflatoxin B1, to achieve rapid, simple and high sensitivity detection of aflatoxin B1, a non-sugar target, has a wide range of application prospects. |
| biological activity | Aflatoxin B1 (AFB1) is a class 1A carcinogen and is a secondary metabolite of Aspergillus flavus and a parasiticus. Aflatoxin B1 (AFB1) mainly induces mutations by inducing G --> amp; gt; T at the third site of the codon 249 in the tumor suppressor gene p53. |
| category | toxic substances |
| toxicity classification | highly toxic |
| acute toxicity | oral-rat LD50:4.80 mg/kg; Oral-mouse LD50: 9 mg/kg |
| flammability hazard characteristics | combustible; combustion releases stimulating smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 18:58:34
Supplier List
Featured ProductsSpot supply
Product Name: Aflatoxin B1 Visit Supplier Webpage Request for quotationCAS: 1162-65-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Featured ProductsMultiple SpecificationsSpot supply
Product Name: AflatoxinB1 Visit Supplier Webpage Request for quotationCAS: 1162-65-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: Aflatoxin B1 Request for quotationCAS: 1162-65-8
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Aflatoxin B1 Visit Supplier Webpage Request for quotationCAS: 1162-65-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Aflatoxin B1 Visit Supplier Webpage Request for quotationCAS: 1162-65-8
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Featured ProductsSpot supply
Product Name: Aflatoxin B1 Visit Supplier Webpage Request for quotationCAS: 1162-65-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Featured ProductsMultiple SpecificationsSpot supply
Product Name: AflatoxinB1 Visit Supplier Webpage Request for quotationCAS: 1162-65-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: Aflatoxin B1 Request for quotationCAS: 1162-65-8
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Aflatoxin B1 Visit Supplier Webpage Request for quotationCAS: 1162-65-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Aflatoxin B1 Visit Supplier Webpage Request for quotationCAS: 1162-65-8
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
View History