116539-55-0
(S)-3-Methylamino-1-(2-thienyl)-1-propanol
CAS: 116539-55-0
Molecular Formula: C8H13NOS
116539-55-0 - Names and Identifiers
116539-55-0 - Physico-chemical Properties
| Molecular Formula | C8H13NOS |
| Molar Mass | 171.26 |
| Density | 1.128±0.06 g/cm3(Predicted) |
| Melting Point | 72.0 to 76.0 °C |
| Boling Point | 294.3±35.0 °C(Predicted) |
| Flash Point | 131.781°C |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.001mmHg at 25°C |
| Appearance | Solid |
| Color | Off-White to Pink |
| pKa | 13.77±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.553 |
| MDL | MFCD07357308 |
| Use | Duloxetine intermediate |
116539-55-0 - Reference Information
| Properties | 3-methylamino-1-(2-thienyl)-1-propanol is gray or pink at room temperature and pressure Solid. |
| Uses | 3-methylamino-1-(2-thienyl)-1-propanol is a synthetic intermediate of serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor duloxetine, a selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor. The mechanism of duloxetine's antidepressant and central analgesia is not yet clear, but it is believed that it is related to its enhancement of serotonergic and noradrenergic function in the central nervous system. |
| preparation method | add N-methyl-N-isobutoxycarbonyl -3-hydroxy -3-(2-thienyl) propylamine 114.8mg(0.42mmol) and 2-propanol 5ml into a 1L four-necked flask equipped with a dropping funnel, a stirrer, a cooling tube and a thermometer, 0.2g of sodium hydroxide aqueous solution with a volume fraction of 30% was added and allowed to react at 30 degrees for 24 hours. After the reaction is completed, the reaction solution is concentrated, the residue is extracted with ethyl acetate, the combined ethyl acetate layer is dried with anhydrous sodium sulfate, the solvent is dried in vacuum, and the residue is purified by silica gel column chromatography to obtain 3-Methylamino -1-(2-thienyl)-1-propanol with a yield of 92%. Fig. 3-synthesis route of methylamino -1-(2-thienyl)-1-propanol |
Last Update：2024-04-09 21:04:16
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Product Name: S-(-)3-Methylamino-1-(2-Thienyl)-1-Propanol Visit Supplier Webpage Request for quotationCAS: 116539-55-0
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View History
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