118081-34-8
Ceftibuten dihydrate
CAS: 118081-34-8
Molecular Formula: C15H14N4O6S2.2H2O
118081-34-8 - Names and Identifiers
| Name | Ceftibuten dihydrate |
| Synonyms | Cetb Cedax Sch-39720 Cedax (tn) CEDAX DIHYDRATE Cedax dihydrate Ceftibuten (jp15) Sch-39720 dihydrate SCH-39720 DIHYDRATE Ceftibuten dihydrate (+)-(6r,7r)-7-[2-(2-amino-1,3-thiazol-4-yl)-4-carboxy-2-butenamide]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrate (+)-(6R,7R)-7-[2-(2-Amino-1,3-thiazol-4-yl)-4-carboxy-2-butenamide]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrate (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-4-carboxybut-2-enoyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrate |
| CAS | 118081-34-8 |
| InChI | InChI=1/C15H14N4O6S2.2H2O/c16-15-17-7(5-27-15)6(1-2-9(20)21)11(22)18-10-12(23)19-8(14(24)25)3-4-26-13(10)19;;/h1,3,5,10,13H,2,4H2,(H2,16,17)(H,18,22)(H,20,21)(H,24,25);2*1H2/b6-1-;;/t10-,13-;;/m1../s1 |
118081-34-8 - Physico-chemical Properties
| Molecular Formula | C15H14N4O6S2.2H2O |
| Molar Mass | 446.459 |
| Melting Point | >180°C (dec.) |
| Boling Point | 966.4°C at 760 mmHg |
| Flash Point | 538.3°C |
| Solubility | DMSO (Slightly), Water (Slightly) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Solid |
| Color | Pale Yellow to Light Orange |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Stability | Hygroscopic |
| In vitro study | Ceftibuten (Sch39720) is highly active against Haemophilus influenza , Escherichia coli , Klebsiella sp., and Proteus sp. and moderately active against Serratia sp. and Streptococcus pyogenes . Ceftibuten is relatively inactive against enterococci and staphylococci and is only weakly active against Pseudomonas aeruginosa and obligate anaerobes. It is also stable in the presence of most β-lactamase-producing organisms except β Bacteroides fragilis . Ceftibuten is very active against strains of the family Enterobacteriaceae (mean MIC for 90% of strains=0.25 μg/ml) but less active against Campylobacterjejuni (mean MIC for 90% of strains=16.0 μg/ml). |
| In vivo study | Ceftibuten, a biologically stableβ-lactam antibiotic, has been shown to be transported by the small peptide transport system, to have relatively high affinity for the carrier and to show clear stereoselective and proton-gradient dependent transport characteristics in rat intestinal brush-border membrane vesicles. |
118081-34-8 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.24 ml | 11.199 ml | 22.399 ml |
| 5 mM | 0.448 ml | 2.24 ml | 4.48 ml |
| 10 mM | 0.224 ml | 1.12 ml | 2.24 ml |
| 5 mM | 0.045 ml | 0.224 ml | 0.448 ml |
Last Update：2024-01-02 23:10:35
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