118488-18-9
fmoc-O-tert-butyl-D-tyrosine
CAS: 118488-18-9
Molecular Formula: C28H29NO5
118488-18-9 - Names and Identifiers
| Name | fmoc-O-tert-butyl-D-tyrosine |
| Synonyms | Fmoc-D-Tyr(tBu)-OH Fmoc-D-Tyr(But)-OH FMOC-O-T-BUTYL-D-TYROSINE fmoc-O-tert-butyl-D-tyrosine FMOC-O-TERT-BUTYL-D-TYROSINE N-α-Fmoc-O-tert-butyl-D-tyrosine Fmoc-D-Tyr(tBu)-OH (Fmoc-O-tert-butyl-D-tyrosine) 9-fluorenylmethyloxycarbonyl-D-tyrosine(tert-butyl)-OH NALPHA-9-Fluorenylmethoxycarbonyl-O-tert-butyl-D-tyrosine O-tert-butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-tyrosine (R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-tert-butoxyphenyl)propanoic acid |
| CAS | 118488-18-9 |
| InChI | InChI=1/C28H29NO5/c1-28(2,3)34-19-14-12-18(13-15-19)16-25(26(30)31)29-27(32)33-17-24-22-10-6-4-8-20(22)21-9-5-7-11-23(21)24/h4-15,24-25H,16-17H2,1-3H3,(H,29,32)(H,30,31)/t25-/m1/s1 |
118488-18-9 - Physico-chemical Properties
| Molecular Formula | C28H29NO5 |
| Molar Mass | 459.53 |
| Density | 1.218±0.06 g/cm3(Predicted) |
| Melting Point | 150.0 to 154.0 °C |
| Boling Point | 658.2±55.0 °C(Predicted) |
| Flash Point | 351.9°C |
| Water Solubility | Soluble in 1 mmole in 2 ml dimethylformamide (Clearly soluble). Slightly soluble in water. |
| Vapor Presure | 3.2E-18mmHg at 25°C |
| Appearance | White powder with lumps |
| BRN | 6691868 |
| pKa | 2.97±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.599 |
| MDL | MFCD00065684 |
118488-18-9 - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29224999 |
118488-18-9 - Introduction
Fmoc-O-tert-butyl-D-tyrosine is a commonly used protected amino acid. The following is a description of its nature, use, formulation and safety information:
Nature:
Fmoc-O-tert-butyl-D-tyrosine is a white crystalline solid. It is an organic compound with the chemical formula C30H31NO7 and a molecular weight of 521.57g/mol. The compound is a derivative of tyrosine in which the amino group bears an Fmoc (9-fluorofluorenylformyl) protecting group and the carboxylic acid group is esterified with O-tert-butyl.
Use:
Fmoc-O-tert-butyl-D-tyrosine is commonly used as a protected amino acid in peptide synthesis. By attaching the Fmoc protecting group to the amino group, unwanted side reactions can be prevented during the synthesis. It is widely used in solid phase synthesis and can be used to synthesize polypeptides and proteins.
Preparation Method:
The preparation of Fmoc-O-tert-butyl-D-tyrosine is generally carried out by chemical synthesis. First, tyrosine is reacted with Fmoc-Cl (9-fluorofluorenylcarbonyl chloride) to produce Fmoc-O-tyrosine. Cesium tert-butyl bromide is then added to the reaction to esterify the carboxylic acid group to form Fmoc-O-tert-butyl-D-tyrosine. Finally, the pure product is obtained by the steps of crystallization, washing and drying.
Safety Information:
Fmoc-O-tert-butyl-D-tyrosine is a stable compound under normal conditions and has no obvious volatilization at room temperature. During use, it is necessary to comply with laboratory safety procedures, wear appropriate protective equipment, and avoid contact with skin and eyes. When handling or storing, it should be kept in a dry, cool place and away from fire and oxidizing agents. At the same time, contact with strong oxidants and strong acids should be avoided to prevent dangerous reactions. Seek immediate medical help if ingestion or accidental exposure to the compound.
Nature:
Fmoc-O-tert-butyl-D-tyrosine is a white crystalline solid. It is an organic compound with the chemical formula C30H31NO7 and a molecular weight of 521.57g/mol. The compound is a derivative of tyrosine in which the amino group bears an Fmoc (9-fluorofluorenylformyl) protecting group and the carboxylic acid group is esterified with O-tert-butyl.
Use:
Fmoc-O-tert-butyl-D-tyrosine is commonly used as a protected amino acid in peptide synthesis. By attaching the Fmoc protecting group to the amino group, unwanted side reactions can be prevented during the synthesis. It is widely used in solid phase synthesis and can be used to synthesize polypeptides and proteins.
Preparation Method:
The preparation of Fmoc-O-tert-butyl-D-tyrosine is generally carried out by chemical synthesis. First, tyrosine is reacted with Fmoc-Cl (9-fluorofluorenylcarbonyl chloride) to produce Fmoc-O-tyrosine. Cesium tert-butyl bromide is then added to the reaction to esterify the carboxylic acid group to form Fmoc-O-tert-butyl-D-tyrosine. Finally, the pure product is obtained by the steps of crystallization, washing and drying.
Safety Information:
Fmoc-O-tert-butyl-D-tyrosine is a stable compound under normal conditions and has no obvious volatilization at room temperature. During use, it is necessary to comply with laboratory safety procedures, wear appropriate protective equipment, and avoid contact with skin and eyes. When handling or storing, it should be kept in a dry, cool place and away from fire and oxidizing agents. At the same time, contact with strong oxidants and strong acids should be avoided to prevent dangerous reactions. Seek immediate medical help if ingestion or accidental exposure to the compound.
Last Update：2024-04-10 22:29:15
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View History
118488-18-9
108714-73-4
60857-08-1
118-90-1
CCG-63808
N-Dodecan
2192-20-3
C.I. 561170
Amyloid β-Protein (3-42)
75693-16-2
108714-73-4
60857-08-1
118-90-1
CCG-63808
N-Dodecan
2192-20-3
C.I. 561170
Amyloid β-Protein (3-42)
75693-16-2