1191911-27-9
CZC-54252
CAS: 1191911-27-9
Molecular Formula: C22H25ClN6O4S
1191911-27-9 - Names and Identifiers
1191911-27-9 - Physico-chemical Properties
| Molecular Formula | C22H25ClN6O4S |
| Molar Mass | 504.99 |
| Density | 1.452±0.06 g/cm3(Predicted) |
| Boling Point | 718.1±70.0 °C(Predicted) |
| Solubility | DMSO: 21 mg/mL |
| pKa | 8.50±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| In vitro study | CZC-54252 inhibits the activity of recombinant human wild-type LRRK2 with an IC 50 ranging from ～1 to ～5 nM. The G2019S mutant is inhibited with an IC 50 ranging from ～2 to ～7 nM in a TF-FRET assay. In addition, they are screened against a kinase panel of 185 kinases and exhibited good selectivity. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 with an EC 50 of ~1 nM and fully reversed to wild-type levels by CZC-54252 at concentration of 1.6 nM. |
1191911-27-9 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.98 ml | 9.901 ml | 19.802 ml |
| 5 mM | 0.396 ml | 1.98 ml | 3.96 ml |
| 10 mM | 0.198 ml | 0.99 ml | 1.98 ml |
| 5 mM | 0.04 ml | 0.198 ml | 0.396 ml |
Last Update：2024-01-02 23:10:35
1191911-27-9 - Reference Information
| biological activity | CZC-54252 is an effective LRRK2 inhibitor with IC50 of 1.28 nM and 1.85 nM for human wild type LRRK2 and G2019S LRRK2 respectively. |
| target | TargetValue LRRK2 (WT) (Cell-free say) 1.28 nM LRRK2 (G2019S) (Cell-free say) 1.85 nM |
| Target | Value |
| LRRK2 (WT) (Cell-free assay) | 1.28 nM |
| LRRK2 (G2019S) (Cell-free assay) | 1.85 nM |
| in vitro study | CZC-54252 inhibits the activity of recombinant human wild-type LRRK2 with an IC 50 ranging from ~ 1 to ~ 5 nM. The G2019S mutant is inhibited with an IC 50 ranging from ~ 2 to ~ 7 nM in a TF-FRET say. In addition, they are screened against a kinase panel of 185 kinases and exhibited good selectivity. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 with an EC 50 of ~ 1 nM and fully reversed to wild-type levels by CZC-54252 at concentration of 1.6 nM. |
Last Update：2024-04-09 15:16:38
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View History
1191911-27-9
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D-半乳糖酸钙
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