119262-68-9
Scutellarin methlester
CAS: 119262-68-9
Molecular Formula: C22H20O12
119262-68-9 - Names and Identifiers
119262-68-9 - Physico-chemical Properties
| Molecular Formula | C22H20O12 |
| Molar Mass | 476.39 |
| Density | 1.697±0.06 g/cm3(Predicted) |
| Boling Point | 804.0±65.0 °C(Predicted) |
| Solubility | Soluble in methanol |
| Appearance | Yellow needle crystal or powder |
| pKa | 5.92±0.40(Predicted) |
| Storage Condition | 2-8℃ |
| MDL | MFCD29049472 |
119262-68-9 - Reference Information
| effect | the improvement effect of scutellarin methyl ester on ischemic brain tissue The experiment shows that scutellarin methyl ester can effectively improve the local cerebral blood flow of ischemia-reperfusion in rats and significantly reduce the degree of ischemic injury of brain tissue. The mechanism may be to inhibit cerebral vasospasm contraction caused by protein kinase activation, increase local cerebral blood flow, improve cerebral microcirculation, reduce inflammatory cell adhesion infiltration, thereby reducing brain damage. |
| mode of action | methyl scutellarin mainly inhibits the formation of thrombus in vitro through three links, reducing platelet count and inhibiting platelet aggregation function, inhibiting coagulation function in vivo and promoting fibrinolytic activity, of which the latter two have stronger effects. Neicalin methyl ester has inhibitory effect on platelet aggregation induced by adenodiphosphate, but it has no effect on platelet aggregation induced by thrombin and epinephrine, and can also inhibit the increase of free calcium ion concentration in platelets. |
| biological activity | Scutellarin methyl ester is a component of breviscapine, which is a crude extract of several flavonoids in breviscapine. |
Last Update：2024-04-09 19:05:04
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