119637-67-1
Moguisteine
CAS: 119637-67-1
Molecular Formula: C16H21NO5S
119637-67-1 - Names and Identifiers
| Name | Moguisteine |
| Synonyms | Moguisteine 2-(2-METHOXYPHENOXY)METHYL-1,3-THIAZOLIDINE ethyl 3-(2-((2-methoxyphenoxy)methyl)thiazolidin-3-yl)-3-oxopropanoate ethyl 3-{2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidin-3-yl}-3-oxopropanoate ethyl 3-[2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidin-3-yl]-3-oxopropanoate (R,S)-2-(2-Methoxyphenoxy)-methyl-3-ethoxycarbonyl-acetyl-1,3 thiazolidine ethyl 3-[2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidin-3-yl]-3-oxo-propanoate 3-keto-3-[2-[(2-methoxyphenoxy)methyl]thiazolidin-3-yl]propionic acid ethyl ester |
| CAS | 119637-67-1 |
| EINECS | 1806241-263-5 |
| InChI | InChI=1/C16H21NO5S/c1-3-21-16(19)10-14(18)17-8-9-23-15(17)11-22-13-7-5-4-6-12(13)20-2/h4-7,15H,3,8-11H2,1-2H3 |
119637-67-1 - Physico-chemical Properties
| Molecular Formula | C16H21NO5S |
| Molar Mass | 339.41 |
| Density | 1.225±0.06 g/cm3(Predicted) |
| Melting Point | 72-76°C |
| Boling Point | 506.8±50.0 °C(Predicted) |
| Flash Point | 260.3°C |
| Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 2.16E-10mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 13.49±0.40(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Refractive Index | 1.548 |
| In vitro study | The efficacy of Moguisteine was confirmed to be comparable to that of codeine in experimental models of induced cough in guinea pigs and dogs. It acts neither through opioid receptors nor through the cough center, but may function along the bronchial tree by interacting with rapidly adapting stimulatory receptors. In controlled clinical trials, Moguisteine is safe and effective in reducing cough-related symptoms, such as respiratory disorders caused by upper respiratory tract infections, chronic bronchitis, pulmonary fibrosis, and malignancies. |
119637-67-1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.946 ml | 14.732 ml | 29.463 ml |
| 5 mM | 0.589 ml | 2.946 ml | 5.893 ml |
| 10 mM | 0.295 ml | 1.473 ml | 2.946 ml |
| 5 mM | 0.059 ml | 0.295 ml | 0.589 ml |
Last Update：2024-01-02 23:10:35
119637-67-1 - Reference Information
| biological activity | Moguisteine is a new type of peripheral non-narcotic cough medicine, and its efficacy has been proved to be equivalent to codeine in experimental models of cough-inducing guinea pigs and dogs. It acts neither through opioid receptors nor through the cough center, but may function along the bronchial tree by interacting with rapidly adapted stimulatory receptors. In controlled clinical trials, moguisteine is safe and can effectively reduce cough-related symptoms, such as respiratory disorders caused by upper respiratory tract infection, chronic bronchitis, pulmonary fibrosis and malignant tumors. |
Last Update：2024-04-09 21:54:55
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