1200-22-2
R-alpha-Lipoic Acid
CAS: 1200-22-2
Molecular Formula: C8H14O2S2
1200-22-2 - Names and Identifiers
| Name | R-alpha-Lipoic Acid |
| Synonyms | D-lipoic acid R-Alpha Lipoic Acid R-alpha-Lipoic Acid (R)-(+)-1,2-Dithiola R(+)Alpha Lipoic Acid R(+)alpha-lipoic acid R-(+)-alpha-Lipoic acid 5-[(3R)-dithiolan-3-yl]valeric acid 5-[(3R)-dithiolan-3-yl]pentanoic acid (R)-(+)-1,2-Dithiolane-3-pentanoic acid (R)-(+)-1,2-Dithiolane-3-Pentanoic Acid (R)-5-(1,2-Dithiolan-3-yl)pentanoic acid 5-[(3R)-1,2-dithiolan-3-yl]pentanoic acid (R)-Thioctic Acid(R)-1,2-Dithiolane-3-valeric Acid |
| CAS | 1200-22-2 |
| EINECS | 638-752-2 |
| InChI | InChI=1/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1 |
1200-22-2 - Physico-chemical Properties
| Molecular Formula | C8H14O2S2 |
| Molar Mass | 206.33 |
| Density | 1.218±0.06 g/cm3(Predicted) |
| Melting Point | 48-52°C(lit.) |
| Boling Point | 185-195 °C(Press: 0.5 Torr) |
| Specific Rotation(α) | D23 +104° (c = 0.88 in benzene) |
| Flash Point | >230°F |
| Solubility | Soluble in Dimethyl Sulfoxide and Methanol |
| Appearance | Yellow crystalline solid |
| Color | Light Yellow to Yellow Low-Melting |
| Merck | 14,9326 |
| pKa | 5.4(at 25℃) |
| Storage Condition | -20°C |
| Sensitive | `sensitive` to light, heat, air and humidity |
| Refractive Index | 114 ° (C=1, EtOH) |
| MDL | MFCD01631142 |
| Use | Vitamin drugs, the effect is better than lipoic acid. |
| In vitro study | Lipoic acid ((R)-(+)-α-Lipoic acid) is the form biosynthesized in humans which is essential for aerobic metabolism. Lipoic acid ((R)-(+)-α-Lipoic acid) is the nutritionally and therapeutically preferred form due to its "vitamin-like" role in metabolism. Lipoic acid ((R)-(+)-α-Lipoic acid) and S-(-)-α-Lipoic acid) constitute the racemic mixture Lipoic acid. Only the Lipoic acid ((R)-(+)-α-Lipoic acid) exists in nature and is an essential cofactor of four mitochondrial enzyme complexes. Lipoic acid ((R)-(+)-α-Lipoic acid) has been suggested to be nutritionally and therapeutically preferred form as antioxidant. |
1200-22-2 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/38 - Irritating to eyes and skin. |
| Safety Description | S20 - When using, do not eat or drink. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S35 - This material and its container must be disposed of in a safe way. |
| WGK Germany | 3 |
| HS Code | 29349990 |
1200-22-2 - Reference Information
| found | R-( )-lipoic acid is a yellow crystalline substance. Lipoic acid is a natural product with biological activity. In 1951, Raed et al. reported that a crystalline cofactor of a growth-promoting enzyme was isolated from treated insoluble liver tissue residues. Because of its high fat solubility and acidity (pka = 4.7), this compound was named lipoic acid. |
| physiological function | lipoic acid is an endogenous antioxidant, which can remove free radicals in the body, promote the body to use glucose to synthesize vitamin C, and promote the synthesis of glutathione. It can effectively remove melanin and assist coenzymes in physiological metabolism that is beneficial to the body's immunity. Lipoic acid also has anti-inflammatory effect, can inhibit the activity of kinase, transforming factor, tumor necrosis factor and collagenase, and has anti-aging effect. Lipoic acid can preserve and regenerate other antioxidants, and has a good health effect on the human body. It is currently widely used in the prevention and treatment of heart disease, diabetes, liver disease and Alzheimer's disease. The two enantiomers of lipoic acid show different biological activities. Among them, the R-type enantiomer is much more effective than the S-type. This may be due to the metabolism of lipoic acid, a large amount of R-type lipoic acid can penetrate the cell membrane and mitochondrial membrane into the cell and mitochondria It is reduced to dihydrolipoic acid, while only a small amount of S-type enters the cell and is reduced. Dihydrolipoic acid has stronger antioxidant capacity than lipoic acid. The regeneration of endogenous antioxidants and the repair of oxidative damage need to be achieved in the form of dihydrolipoic acid. |
| Biological activity | ( )-α-Lipoic acid ((R)-( )-α-Lipoic acid, α-Lipoic acid, Alpha-Lipoic acid) is one of the physiological forms of thioctic acid. It is a powerful antioxidant that can reduce diabetic neurological symptoms. It has superior oxidation resistance than its racemate. R (+)-α-lipoic acid is an essential cofactor of the mitochondrial enzyme complex. R( )-α-lipoic acid inhibits NF-κB-dependent HIV-1 LTR activation. |
| Target | Value |
| use | vitamin drugs, the effect is better than lipoic acid. |
Last Update：2024-04-09 15:16:47
Supplier List
Featured ProductsSpot supply
Product Name: (|R|)-(+)-1,2-Dithiolane-3-pentanoic acid Visit Supplier Webpage Request for quotationCAS: 1200-22-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Lipoic acid Request for quotationCAS: 1200-22-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Lipoic acid Visit Supplier Webpage Request for quotationCAS: 1200-22-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Lipoic acid (Standard) Visit Supplier Webpage Request for quotationCAS: 1200-22-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: (R)-alpha-Lipoic Acid Visit Supplier Webpage Request for quotationCAS: 1200-22-2
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: (R)-LIPOIC ACID Visit Supplier Webpage Request for quotationCAS: 1200-22-2
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: R-alpha-Lipoic Acid Request for quotation
CAS: 1200-22-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 1200-22-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: (R)-(+)-1,2-Dithiolane-3-pentanoic acid Visit Supplier Webpage Request for quotationCAS: 1200-22-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Product Name: (R)-(+)-1,2-Dithiolane-3-pentanoic acid Request for quotation
CAS: 1200-22-2
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
CAS: 1200-22-2
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
Multiple Specifications
Product Name: D-Lipoic Acid Request for quotationCAS: 1200-22-2
Tel: 18888297294
Email: kenny@hychemchina.com
Mobile: 18888297294
QQ: 3440845085
Featured ProductsSpot supply
Product Name: (|R|)-(+)-1,2-Dithiolane-3-pentanoic acid Visit Supplier Webpage Request for quotationCAS: 1200-22-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Lipoic acid Request for quotationCAS: 1200-22-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Lipoic acid Visit Supplier Webpage Request for quotationCAS: 1200-22-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Lipoic acid (Standard) Visit Supplier Webpage Request for quotationCAS: 1200-22-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: (R)-alpha-Lipoic Acid Visit Supplier Webpage Request for quotationCAS: 1200-22-2
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: (R)-LIPOIC ACID Visit Supplier Webpage Request for quotationCAS: 1200-22-2
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: R-alpha-Lipoic Acid Request for quotation
CAS: 1200-22-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 1200-22-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: (R)-(+)-1,2-Dithiolane-3-pentanoic acid Visit Supplier Webpage Request for quotationCAS: 1200-22-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Product Name: (R)-(+)-1,2-Dithiolane-3-pentanoic acid Request for quotation
CAS: 1200-22-2
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
CAS: 1200-22-2
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228
Wechat: +8613651600618
WhatsApp: +8613651600618
Multiple Specifications
Product Name: D-Lipoic Acid Request for quotationCAS: 1200-22-2
Tel: 18888297294
Email: kenny@hychemchina.com
Mobile: 18888297294
QQ: 3440845085
View History