120166-69-0
diacylglycerol kinase inhibitor ii
CAS: 120166-69-0
Molecular Formula: C28H25F2N3OS
120166-69-0 - Names and Identifiers
| Name | diacylglycerol kinase inhibitor ii |
| Synonyms | DAG Kinase Inhibitor DAG Kinase Inhibitor II diacylglycerol kinase inhibitor ii DIACYLGLYCEROL KINASE INHIBITOR II DIACYLGLYCEROL KINASE INHIBITOR I (R59 949) 3-[2-[4-Bis(4-fluorophenyl)methylenepiperidino]ethyl]-2,3-dihydro-2-thioxoquinazolin-4(1H)-one 3-[2-(4-[BIS(4-FLUOROPHENYL)-METHYLENE)-1-PIPERIDINYL)ETHYL]-2,3-DIHYDRO-2-THIOXO-4[1H]-QUINAZOLINONE 3-[2-[4-(bis(4-Fluorophenyl)Methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone, R59949 R59949, 3-[2-[4-(bis(4-Fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone |
| CAS | 120166-69-0 |
| InChI | InChI=1/C28H25F2N3OS/c29-22-9-5-19(6-10-22)26(20-7-11-23(30)12-8-20)21-13-15-32(16-14-21)17-18-33-27(34)24-3-1-2-4-25(24)31-28(33)35/h1-12H,13-18H2,(H,31,35) |
120166-69-0 - Physico-chemical Properties
| Molecular Formula | C28H25F2N3OS |
| Molar Mass | 489.58 |
| Density | 1.36±0.1 g/cm3(Predicted) |
| Melting Point | 228-230 °C |
| Boling Point | 637.1±65.0 °C(Predicted) |
| Flash Point | 339.1°C |
| Solubility | 0.1 M HCl: slightly soluble |
| Vapor Presure | 3.94E-16mmHg at 25°C |
| Appearance | solid |
| Color | pale yellow |
| pKa | 11.24±0.20(Predicted) |
| Storage Condition | -20°C |
| Refractive Index | 1.688 |
| In vitro study | In the presence of R59949, vasopressin- as well as collagen-induced release reaction and aggregation was strongly increased, independently of the formation of arachidonate metabolites. In THP‐1 monocytes, R59949 attenuates CCL2‐evoked Ca 2+ signalling with a half‐maximal concentration of 8.6 μM. R59949 inhibits inducible nitric oxide production through decreasing transplasmalemmal L-arginine uptake in vascular smooth muscle cells. |
120166-69-0 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
120166-69-0 - Reference Information
| Biological activity | R59949 is a pan-diacylglycerol kinase (DGK) inhibitor with IC50 of 300 nM. R59949 strongly inhibited the activity of type I DGKα and γ, and moderately weakened the activity of type II DGKθ and κ. R59949 activates protein kinase C (PKC) by increasing the level of endogenous ligand diacylglycerol. |
Last Update：2024-04-09 20:52:54
Supplier List
Featured ProductsSpot supply
Product Name: Diacylglycerol Kinase Inhibitor II Visit Supplier Webpage Request for quotationCAS: 120166-69-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 3-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one Request for quotationCAS: 120166-69-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: R59949 Visit Supplier Webpage Request for quotationCAS: 120166-69-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: R59949 Visit Supplier Webpage Request for quotationCAS: 120166-69-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Featured ProductsSpot supply
Product Name: Diacylglycerol Kinase Inhibitor II Visit Supplier Webpage Request for quotationCAS: 120166-69-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 3-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one Request for quotationCAS: 120166-69-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: R59949 Visit Supplier Webpage Request for quotationCAS: 120166-69-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: R59949 Visit Supplier Webpage Request for quotationCAS: 120166-69-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
View History