1214-47-7

1214-47-7 - Names and Identifiers

Name	1-(2-hydroxyphenyl)-3-phenyl-2-propenone
Synonyms	2-HYDROXYCHALC 2-Hydroxychalcone 2'-Hydroxychalcone 6'-Hydroxychalcone HYDROXYCHALCONE, 2'- 2-Hydroxyphenylstyryl ketone 2'-HYDROXY BENZALACETOPHENONE Benzylidene(2-hydroxyacetophenone) 1-(2-hydroxyphenyl)-3-phenyl-2-propenone 3-Phenyl-1-(2-hydroxyphenyl)-2-propen-1-one 1-(2-Hydroxyphenyl)-3-phenyl-2-propen-1-one (E)-1-(2-HYDROXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE 2μ-Hydroxychalcone, 2-Hydroxybenzalacetophenone (2E)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one 2-Benzal-2'-hydroxyacetophenone2-Benzylidene-2'-hydroxyacetophenone
CAS	1214-47-7
EINECS	214-928-0
InChI	InChI=1/C15H12O2/c16-14-9-5-4-8-13(14)15(17)11-10-12-6-2-1-3-7-12/h1-11,16H/b11-10+

1214-47-7 - Physico-chemical Properties

Molecular Formula	C15H12O2
Molar Mass	224.25
Density	1.191±0.06 g/cm3 (20 ºC 760 Torr)
Melting Point	86-88°C(lit.)
Boling Point	396.6±42.0 °C(Predicted)
Flash Point	169.4°C
Solubility	Very slightly soluble (0.2g/L) (25°C),
Vapor Presure	7.4E-07mmHg at 25°C
Appearance	grayish yellow powder
BRN	976324
pKa	7.77±0.30(Predicted)
Storage Condition	Store below +30°C.
Sensitive	Sensitive to light
Refractive Index	1.653
MDL	MFCD00016441
Physical and Chemical Properties	Yellow needle-like crystals (ethanol). Melting point 88-89 °c.

1214-47-7 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
RTECS	UD5579400
FLUKA BRAND F CODES	8
TSCA	Yes
HS Code	29145090

1214-47-7 - Reference

Reference

1. [IF=4.225] Qian Yun et al."2′-Hydroxychalcone Induced Cytotoxicity via Oxidative Stress in the Lipid-Loaded Hepg2 Cells."Front Pharmacol. 2019 Nov;0:1390

1214-47-7 - Reference Information

EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
Overview	2 '-hydroxychalcone can be used as an intermediate in drug synthesis, such as the preparation of flavonols. Flavonoids and alcohols are widely distributed in nature as secondary metabolites in organisms. Because of their various physiological activities, they have attracted extensive attention at home and abroad. At present, the biological activities of flavonoids are mainly studied on cardiovascular system, antiviral, anti-inflammatory and anti-tumor effects.
preparation	2 '-hydroxychalcone preparation: 30ml of 20%(V/V) ethanol and (11.06mmol) sodium hydroxide are added into a 50mL single-mouth flask, stirred for 0.5h at room temperature, then substituted 2-hydroxyacetophenone (1.66mmol) and benzaldehyde (1.66mmol) are added, and stirred for 18h at room temperature, TLC monitored that the raw material point produced by the new point would not change any more, stopped the reaction, poured the reactant into water, stirred and adjusted the PH value to acidity with 6mol/ L hydrochloric acid, filtered the reactant to obtain a filter cake, washed twice with purified water, and obtained 2'-hydroxychalcone by silica gel column chromatography [V (petroleum ether): V (ethyl acetate) = 5: 1] with 85% yield.
uses	intermediates of propafenone.
production method	1. preparation method: o-hydroxyacetophenone (2)13.6g(0.1mol), sodium hydroxide 16g(0.4mol), water 100mL and tetrabutylammonium bromide 0.05g are added to a reaction bottle equipped with a stirrer, a thermometer, a reflux condenser and a dropping funnel. Under stirring, slowly heat to 50 ℃, add 14.8g(0.14mol) of benzaldehyde dropwise within 20min. After adding, the temperature is raised to 70 ℃, and the heat preservation reaction is 3 hours. Cool to room temperature and adjust to PH1 with concentrated hydrochloric acid about 40mL. Extraction filtration, water washing. The filter cake was recrystallized with ethanol and dried under reduced pressure at 40 ℃ to obtain 19.9g of light yellow powder solid (1) with a yield of 88.8%,mp88~89 ℃. [1]
spontaneous combustion temperature	280°C

Last Update：2024-04-09 20:52:54

Shanghai Macklin Biochemical Co., Ltd

Featured ProductsSpot supply

Product Name: 1-(2-Hydroxyphenyl)-3-phenyl-2-propenone Visit Supplier Webpage Request for quotation
CAS: 1214-47-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328

WhatsApp: +86-18821248368

Shanghai Amole Biotechnology Co., Ltd.

Spot supply

Product Name: 2'-Hydroxychalcone Request for quotation
CAS: 1214-47-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365

Wechat: 18916960931

SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.

Spot supply

Product Name: 1-(2-Hydroxyphenyl)-3-phenyl-2-propenone Visit Supplier Webpage Request for quotation
CAS: 1214-47-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922

Wechat: 18621343501
WhatsApp: +86-18621343501

MedChemExpress (MCE)

Spot supply

Product Name: 2′-Hydroxychalcone Visit Supplier Webpage Request for quotation
CAS: 1214-47-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898