122-07-6
Methylaminoacetaldehyde dimethyl acetal
CAS: 122-07-6
Molecular Formula: C5H13NO2
122-07-6 - Names and Identifiers
122-07-6 - Physico-chemical Properties
| Molecular Formula | C5H13NO2 |
| Molar Mass | 119.16 |
| Density | 0.928 g/mL at 25 °C (lit.) |
| Melting Point | -73°C |
| Boling Point | 140 °C (lit.) |
| Flash Point | 85°F |
| Water Solubility | miscible |
| Vapor Presure | 6.26mmHg at 25°C |
| Appearance | liquid &_& neat |
| Color | Colorless to Light yellow to Light orange |
| BRN | 605322 |
| pKa | 8.29±0.20(Predicted) |
| PH | 10.9 (10g/l, H2O, 20℃) |
| Storage Condition | 2-8°C |
| Sensitive | Air Sensitive |
| Refractive Index | n20/D 1.414(lit.) |
122-07-6 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R10 - Flammable R36 - Irritating to the eyes R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S16 - Keep away from sources of ignition. |
| UN IDs | UN 1989 3/PG 3 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 2-10 |
| TSCA | Yes |
| HS Code | 29225000 |
| Hazard Note | Irritant |
| Hazard Class | 3 |
| Packing Group | III |
122-07-6 - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | methylaminoacetaldehyde dimethanol can be used as a pharmaceutical synthesis intermediate, such as the preparation of methimazole, the chemical name is 1-methylimidazole-2-thiol, which is an antithyroid drug. Its mechanism of action is to inhibit peroxidase in the thyroid gland, thus inhibiting the oxidation of iodide and the coupling of tyrosine into the thyroid gland, blocks the synthesis of thyroxine (T4) and triiodothyronine (T3). Animal experiments have observed that B lymphocytes synthesize antibodies, reduce the level of thyroid stimulating antibodies in the blood circulation, and restore the suppressor T cells to normal. |
| preparation | The autoclave was charged with 3.00 of chloroacetaldehyde dimethanol and 33% of methylamine methanol solution, and the autoclave valve was closed, heating Temperature to 130-135 ℃, the maximum pressure of 1.2MPa, and then continue to reduce, heat preservation reaction for 6 hours, cooling to 25 ℃, pressure to neutralization tank. The temperature was lowered to below 10 ° C. With stirring, 40% of 3.26 sodium methoxide methanol solution was added dropwise, and the mixture was kept at 0-5 ° C. For 2-3 hours. After filtration, the filter cake was washed with methanol and the filtrate was transferred to a distillation tank. The methanol was distilled at atmospheric pressure, and the distillation was changed to vacuum distillation. The brine condensation was started to collect the intermediate, and the 52-60 ℃/24mmHg fraction was collected to obtain 2.51kg of methylaminoacetaldehyde dimethanol, with a purity of 94.6% by GC, the yield was 83.1%. |
| Use | methylaminoacetaldehyde dimethanol can be used as a pharmaceutical synthesis intermediate, such as the preparation of methimazole. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
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