122536-75-8
(R)-1-Cbz-3-(Boc-Amino) Pyrrolidine
CAS: 122536-75-8
Molecular Formula: C17H24N2O4
122536-75-8 - Names and Identifiers
122536-75-8 - Physico-chemical Properties
| Molecular Formula | C17H24N2O4 |
| Molar Mass | 320.38 |
| Density | 1.17g/cm3 |
| Boling Point | 458.5°C at 760 mmHg |
| Flash Point | 231.1°C |
| Vapor Presure | 1.37E-08mmHg at 25°C |
| Storage Condition | 2-8°C |
| Refractive Index | 1.549 |
122536-75-8 - Introduction
(R)-1-Cbz-3-Boc-aminopyrrolidine is an organic compound with the following properties:
1. Appearance: colorless or light yellow solid.
2. Solubility: Soluble in some organic solvents such as dichloromethane and methanol.
3. melting point: about 78-82 degrees Celsius.
Use:
(R)-1-Cbz-3-Boc-aminopyrrolidine is a commonly used organic synthesis intermediate, commonly used in the synthesis of drugs and other organic compounds. It can participate in amino acid protection, peptide synthesis and other reactions.
Preparation Method:
(R)-1-Cbz-3-Boc-aminopyrrolidine can be prepared as follows:
First, (R)-1-aminopyrrolidine is reacted with tert-butyl carbonate under basic conditions to produce (R)-1-Cbz-3-tert-butoxycarbonylpyrrolidine. Then, (R)-1-Cbz-3-tert-butoxycarbonylpyrrolidine is reacted with boric acid, glacial acetic acid, diethylamine and the like to obtain (R)-1-Cbz-3-Boc-aminopyrrolidine.
Safety Information:
(R)-1-Cbz-3-Boc-aminopyrrolidine is generally relatively safe under proper conditions of use and storage. However, it may be irritating to the eyes and skin, so be careful to avoid contact when using it. Appropriate personal protective measures, such as wearing gloves, glasses and laboratory coats, are required during handling and handling. During use, the safe operation procedures for chemicals should be followed and the operation should be carried out in a well-ventilated place. In case of accidental exposure or inhalation of the compound, seek medical attention.
1. Appearance: colorless or light yellow solid.
2. Solubility: Soluble in some organic solvents such as dichloromethane and methanol.
3. melting point: about 78-82 degrees Celsius.
Use:
(R)-1-Cbz-3-Boc-aminopyrrolidine is a commonly used organic synthesis intermediate, commonly used in the synthesis of drugs and other organic compounds. It can participate in amino acid protection, peptide synthesis and other reactions.
Preparation Method:
(R)-1-Cbz-3-Boc-aminopyrrolidine can be prepared as follows:
First, (R)-1-aminopyrrolidine is reacted with tert-butyl carbonate under basic conditions to produce (R)-1-Cbz-3-tert-butoxycarbonylpyrrolidine. Then, (R)-1-Cbz-3-tert-butoxycarbonylpyrrolidine is reacted with boric acid, glacial acetic acid, diethylamine and the like to obtain (R)-1-Cbz-3-Boc-aminopyrrolidine.
Safety Information:
(R)-1-Cbz-3-Boc-aminopyrrolidine is generally relatively safe under proper conditions of use and storage. However, it may be irritating to the eyes and skin, so be careful to avoid contact when using it. Appropriate personal protective measures, such as wearing gloves, glasses and laboratory coats, are required during handling and handling. During use, the safe operation procedures for chemicals should be followed and the operation should be carried out in a well-ventilated place. In case of accidental exposure or inhalation of the compound, seek medical attention.
Last Update：2024-04-09 21:01:54
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