1227270-32-7
2-Iodo-1H-pyrrolo[2,3-b]pyridine
CAS: 1227270-32-7
Molecular Formula: C7H5IN2
1227270-32-7 - Names and Identifiers
| Name | 2-Iodo-1H-pyrrolo[2,3-b]pyridine |
| Synonyms | 2-Iodo-7-azaindole 2-Iodo-1H-pyrrolo[2,3-b]p... 2-Iodo-1H-pyrrolo[2,3-b]pyridine 1H-Pyrrolo[2,3-b]pyridine, 2-iodo- |
| CAS | 1227270-32-7 |
1227270-32-7 - Physico-chemical Properties
| Molecular Formula | C7H5IN2 |
| Molar Mass | 244.03 |
| Density | 2.082 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Sensitive | Irritant |
| MDL | MFCD16875827 |
1227270-32-7 - Introduction
2-iodo-7-azaindole is an organic compound with a chemical formula of C9H5IN2 and a structure containing an iodine atom and an azaindole ring. Its properties are as follows:
1. Appearance: yellow to brown crystals or crystalline powder.
2. melting point: about 140-145 ℃.
3. Solubility: Soluble in non-polar solvents (such as chloroform, dichloromethane, etc.), and poor solubility in polar solvents (such as water, ethanol, etc.).
2-iodo-7-azaindole is commonly used in organic synthesis and pharmaceutical fields and has the following uses:
1. As a catalyst: It can be used as a catalyst in organic reactions, such as carbon-nitrogen bond activation in C- C bond formation reaction.
2. as a drug intermediate: in the preparation of certain drugs (such as anti-cancer drugs), 2-iodine -7-azaindole is commonly used as an intermediate to synthesize other compounds.
The preparation of 2-iodo-7-azaindole can be carried out by the following steps:
1. Indole and iodine are reacted in a suitable organic solvent.
2. Add an appropriate amount of solvent and allow the reaction mixture to stir and mix well.
3. Heat the reaction at an appropriate temperature.
4. The product was obtained by filtration, washed and dried to obtain the target compound.
Regarding safety information, 2-iodo-7-azaindole may be harmful to the human body, so the following safety measures should be paid attention to when using:
1. avoid direct contact with skin and eyes, use should wear protective gloves and goggles and other personal protective equipment.
2. Operate in a well-ventilated place to prevent the accumulation of toxic gases.
3. do not inhale dust, avoid exposure to its vapor or smoke.
4. Clean thoroughly after use to avoid undesirable reactions with other chemicals.
5. Store 2-iodo-7-azaindole in a cold dark place to avoid contact with fire and oxygen.
Please note that before performing any experiments or applications, you should carefully understand and comply with laboratory safety regulations and operating methods in relevant literature and operating manuals.
1. Appearance: yellow to brown crystals or crystalline powder.
2. melting point: about 140-145 ℃.
3. Solubility: Soluble in non-polar solvents (such as chloroform, dichloromethane, etc.), and poor solubility in polar solvents (such as water, ethanol, etc.).
2-iodo-7-azaindole is commonly used in organic synthesis and pharmaceutical fields and has the following uses:
1. As a catalyst: It can be used as a catalyst in organic reactions, such as carbon-nitrogen bond activation in C- C bond formation reaction.
2. as a drug intermediate: in the preparation of certain drugs (such as anti-cancer drugs), 2-iodine -7-azaindole is commonly used as an intermediate to synthesize other compounds.
The preparation of 2-iodo-7-azaindole can be carried out by the following steps:
1. Indole and iodine are reacted in a suitable organic solvent.
2. Add an appropriate amount of solvent and allow the reaction mixture to stir and mix well.
3. Heat the reaction at an appropriate temperature.
4. The product was obtained by filtration, washed and dried to obtain the target compound.
Regarding safety information, 2-iodo-7-azaindole may be harmful to the human body, so the following safety measures should be paid attention to when using:
1. avoid direct contact with skin and eyes, use should wear protective gloves and goggles and other personal protective equipment.
2. Operate in a well-ventilated place to prevent the accumulation of toxic gases.
3. do not inhale dust, avoid exposure to its vapor or smoke.
4. Clean thoroughly after use to avoid undesirable reactions with other chemicals.
5. Store 2-iodo-7-azaindole in a cold dark place to avoid contact with fire and oxygen.
Please note that before performing any experiments or applications, you should carefully understand and comply with laboratory safety regulations and operating methods in relevant literature and operating manuals.
Last Update：2024-04-09 20:49:11
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